Lotronex review

Marketed as Lotronex by Prometheus Laboratories Incorporated in San Diego, Alosetron was withdrawn from the market in 2000 because of the occurrence of grave and fatal gastrointestinal side effects. It was eventually reintroduced in 2002, although its availability and use has been controlled and restrained. Therefore, Lotronex turned out to be the first medicament ever returned to the US market after being withdrawn because of safety concerns.

Lotronex is a 5-HT3 antagonist used for the treatment of women with irritable bowel syndrome (IBS) that has diarrhea as the major symptom. There is currently a Prescribing Program for Lotronex (PPL) that patients must undergo before being eligible for Lotronex treatment. Only carefully selected female patients with truly severe cases of diarrhea-predominant IBS may use Lotronex in light of its nigh-fatal gastrointestinal side effects.

Adults are initially dosed with half a milligram twice a day or one milligram once a day with or without food. It can be increased, decreased, maintained, or stopped altogether depending on how the patient reacts to the medicament after four weeks of therapy.

To be more precise, treatment must be stopped if patients who have been taking one milligram of the medicament twice daily have not shown any significant improvement in their IBS. You should not take Lotronex if you're currently constipated. Feel free to consult your doctor for dose details and further instructions.

Typical Lotronex side effects include haemorrhoids, upset stomach, and headache. If any of the above symptoms persist, consult your doctor as soon as you can. You should also report to your doctor immediately if you experience the unlikely but dangerous side effects of depression, bloating, new or sudden worsening of bowel/abdominal/stomach pain, unusually fast pulse, unexplained fever, bloody stools, and constipation.

Serious allergic reaction to Lotronex is very rare but possible, so you should seek emergency medical attention if it ever happens. The symptoms of hypersensitivity to the medicament are as follows: breathing difficulties, dizziness, skin edema, itching, and skin rash. If you notice other side effects not noted above, you should contact your pharmacist or healthcare specialist without delay.

Before Lotronex treatment can begin, you must first inform your doctor of your medical history, especially if you have liver disease. You must also inform your pharmacist or physician if you are allergic to Lotronex or if you have any other allergies. This medicament must not be used if you have certain medical conditions like a history of thrombuss and other blood disorders, diverticulitis, colitis ulcerosa, Crohn's disease, stricture or adhesions, intestinal perforations/complications/obstructions, megacolon, impaired intestinal circulation, ischemic colitis, ileus, and other intestinal disorders.

The elderly must be extra caurinary tract infectionous when using this medicament because their age may make them more sensitive to its side effects, particularly constipation. Additionally, this medicament should only be used when clearly needed during pregnancy. It is also unknown whether Lotronex passes into breast milk or not. You should thoroughly discuss the risks and benefits of this treatment with your doctor.

Lastly, if you experience new or worsening bowel pains, constipation, or blood in your diarrhea or stool, you must promptly cease taking this medicament and seek medical assistance.

Lotronex has the following structural formula:

Chemical structure of lotronex

• Molecular formula of lotronex is C17H18N4O
Lotronex available : 0,5mg tablets and 1mg tablets

Generic name: Alosetron

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