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Lovastatin

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Lovastatin

Lovastatin review





Atherosclerosis is a condition in which fats and cholesterol start forming on the walls of the blood vessels. In this condition, the blood flow gets restricted. As a result the heart works harder than it used to in order to ensure proper blood supply to the organs. The strain on the heart can lead to further problems like hypertension, angina or chest pain and other forms of cardiovascular disease. In some cases, the poor blood supply to the brain can lead to stroke.

Lovastatin is a drug aimed at reducing the production of cholesterol that could block the blood vessels.

Approved by the Food and Drug Administration in 1987, Lovastatin falls under the class of medicines termed as HMG-CoA reductase inhibitors. Essentially, this means that Lovastatin functions by inhibiting the enzymes that are integral to the production of cholesterol. Once Lovastatin starts taking action, it will reduce the levels of cholesterol in the person’s body.

However, Lovastatin cannot work alone. To achieve optimum results, Lovastatin must be coupled with positive lifestyle changes. This includes regular exercise, proper diet, and adequate rest. The diet is extremely important. In order to help Lovastatin improve your condition, you should also be able to reduce your intake of foods that are high in fat and cholesterol.

Lovastatin comes in two types of tablets. The regular tablet is usually taken with your meal at least once a day. Sometimes, the dosage can be increased to twice a day, depending on your condition. The other type is the extended release tablet. These tablets must be taken as a whole. It cannot be crushed or broken. The tablet will slowly release the medication to the body. As such, it is often taken once each day, preferably at night time.

Initially, your physician may give you a lower dosage. If needed, he will gradually increase your dosage to address your symptoms.

Similar to other statin drugs, Lovastatin should not be taken together with Grapefruit juice. Grapefruit juice will expose the patient to very serious side effects. This isbecause Grapefruit juice inhibits certain functions in the body, making it difficult for the person to digest Lovastatin.

Also, if you are taking higher doses of Lovastatin, you should not take other medications that can create negative interactions. This includes forms of fibrates, niacin, and other similar medications. These drugs tend to contribute to a condition called rhabdmyolysis. Rhabdomyolisis generally refers to a disintegration in the muscle fibers. To know more about medications that are compatible with Lovastatin, you should contact your doctor.

Another important thing to remember is that you should not take Lovastatin when you are pregnant or breastfeeding as it may not be safe for the baby.

Lovastatin is usually received well by the body. However, there may still be some side effects. One of the popular side effects is constipation. Other more serious side effects involve fever, unusual bleeding, bruising, yellowing of skin and eyes. The patient may also feel an overall sense of fatigue with some muscle or joint pain. There may also be other complications like rashes, hives and difficulty in breathing. Once these symptoms are observed, stop taking Lovastatin and contact your doctor immediately.

Lovastatin has the following structural formula:

Chemical structure of lovastatin


• Molecular formula of lovastatin is C23H36O7
• Chemical IUPAC Name is 3,5-dihydroxy-7-[6-hydroxy-2-methyl-8-(2-methylbutanoyloxy)-1,2,6,7,8,8a- hexahydronaphthalen-1-yl]-heptanoic acid
• Molecular weight is 424.528 g/mol
Lovastatin available : 10mg tablets, 20mg tablets, 40mg tablets

Generic name: Pravastatin

Brand name(s): Compactin, Elisor, Lipostat, Mevacor, Mevalotin, Mevastatin, Mevinolin, Oliprevin, Pravachol, Pravaselect, Pravastatina, Pravastatine, Pravastatinum, Selectin, Selipran, Vasten

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