Meclastin review

Meclastin is an effective antihistamine that can quickly reduce allergy symptoms within 24 hours. Though there are a number of precautions and side effects to watch out for.

Meclastin is an antihistamine medication having sedative and anticholinergic effects. It is used for the treatment of allergy symptoms including runny nose, skin edema, itchy skin, hives, rash, sneezing, red and teary eyes and pruritus. It is classified as an antipruritic. Meclastin is able to increase capillary dilatation and permeability as well as improve gastrointestinal and respiratory smooth muscle contraction.

Depending on the dose taken, Meclastin can cause paradoxical effects like CNS depression and stimulation. By blocking the effects of natural-occurring histamine, it inhibits histamine's vasodilator and vasoconstrictor effects. The medication comes in pills and extended-release pills, which should be taken orally. It is also available as a syrup by the brand name Tavist.

Meclastin can cause many side effects including drowsiness, dry mouth, nose or throat, dizziness, chest congestion, headache, upset stomach, excitability, nervousness, pupil dilation, extra sunlight sensitivity, heart abnormality of heartbeat, sleepiness, enlarged prostate and difficulty urinating. These symptoms should be reported to your doctor, particularly if they become severe. Other reactions include loss of appetite, vision changes and irritability. Some symptoms are mild and will only be present as the body adjusts to the medication. Serious side effects like breathing difficulty, arrhythmia and ear ringing should be reported to your doctor immediately.

Patients with hypersensitivity reactions to the medication should never take it. Those with a history of lung disease, asthma, glaucoma, ulcers, difficulty urinating, enlarged prostate, overactive thyroid, hypertension, seizure and heart disease should consult their doctor before taking this medication. Breastfeeding mothers and pregnant women should talk with their doctors before taking this medication. Also, elderly patients may require lower dosages since they are more sensitive to the medication. Meclastin can interact negatively with medications like MAOIs or monoamine oxidase inihibitors, sedatives, tranquilizers, narcotics and antipsychotics.

Meclastin acts by aggressively binding to H1-receptor sites which makes it a selective histamine H1 antagonist. The sites are then blocked, preventing endogenous histamine from attaching. When endogenous histamine is blocked, it cannot act and cause symptoms and reactions. As a result, the patient experiences temporary relief. The medication is thought to be metabolized in the liver by mono-didemethylation and glucuronide conjugation.

12 patients suffering from anaphylactic reactions were given 1 mg of Meclastin 4 times a day for 3 days. Within the first 24 hours, all patients had reduced symptoms and were completely free of symptoms by the second day. The only drawback was that 10 of the patients reported sleepiness that lasted up to 1 week after treatment was over.

Meclastin is an over-the-counter or OTC medication so a prescription is no longer needed. It is available in almost all pharmacies and doctors' clinics. Check the expiration date and manufacturer upon purchase to ensure quality and freshness. The medication may also be ordered online at certified pharmacies.

Drowsiness is one of the most common side effects of Meclastin so patients should not drive or operate heavy machinery until full effects are realized. Children younger than 12 years old should ask a doctor first to ensure safety. The medication should be stored at room temperature away from sunlight and moisture. Dosage should also be followed religiously and patients should never take more or less than recommended.

Meclastin has the following structural formula:

Chemical structure of meclastin

• Molecular formula of meclastin is C21H26ClNO
• Chemical IUPAC Name is 2-[2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]ethyl]-1-methyl-pyrrolidine
• Molecular weight is 343.89 g/mol
Meclastin available : 1mg tablets

Generic name: Clemastine

Brand name(s): Clemastina, Clemastinum, Mecloprodin, Tavegil, Tavist

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