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Mefloquine

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Mefloquine

Mefloquine review





Mefloquine is a type of medication specifically for the treatment of malaria. It was developed during the 1970s in the United States as a synthetic type of quinine.

Mefloquine is prescribed to adults and children who have malaria, a serious disease caused by mosquito bites and which often result to death. It can also be given to travelers who go to specific areas where the spread of malaria is common. This medication belongs to a class of drugs referred to as antimalarials. This drug works by killing malaria-causing organisms.

Mefloquine is known under the trade name of Lariam which is produced by La Roche and Mefaquine.

Mefloquine is administered orally usually once in a week. It can be given along with milk or food to lower the chances of upset stomach. This drug is best taken with a glass of water. This should never be taken on an empty stomach. This drug can also crushed and placed in water or milk for children who are not able to swallow whole tablets. This should be given to children with food. Children must also not take this with an empty stomach.

Dosage for children may vary according to the weight of the patient. There are chances that a child may vomit a few minutes after taking mefloquine. In case vomiting happens within 30-60 minutes after dosage, it is recommended that children take another half-dose. In case the vomiting persists, the patient should be checked by a doctor.

Travelers who use mefloquine to prevent malaria should take this drug a week before their travel. Upon return from the malaria-stricken area, travelers should continue taking this medication for the next 4 weeks.

This drug should be taken as prescribed by the physician. Patients should not miss any dose of mefloquine. For best results it is recommended that patients take this on the same day for every week

Mefloquine can cause side effects ranging from upset stomach, pain in the stomach, vomiting, nausea, diarrhea, hair loss, fever, dizziness, and drowsiness. Patients may also experience insomnia, weird dreams, and lightheadedness.

More often than not these are side effects that result from the body’s adjustment to the medication. In case these side effects persist, a patient should immediately consult their doctor or pharmacist.

Some of the more serious side effects of mefloquine are muscle pain, seizures, irregular heartbeat, numbness, and changes in vision. Patients may also experience depression, hallucination, confusion, and difficulty in breathing while taking this drug.

Patients should inform their doctors or pharmacists of any allergies particularly to quinine before agreeing to use mefloquine. People suffering from various medical conditions such as anxiety disorder, active depression, psychiatric disorders and seizure disorders should avoid using this medication.

Those who have had heart and liver problems should also inform their doctors of their medical history before agreeing to take mefloquine. This drug can also cause loss of balance among its users, so extreme caution is recommended to those who usually drive or engage in mental and physical activities.

Mefloquine has the following structural formula:

Chemical structure of mefloquine


• Molecular formula of mefloquine is C17H16F6N2O
• Chemical IUPAC Name is [2,8-bis(trifluoromethyl)quinolin-4-yl]-piperidin-2-ylmethanol
• Molecular weight is 378.3122 g/mol
Mefloquine available : 250mg tablets

Brand name(s): Lariam, Mefloquinone

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