Meractinomycin review

Meractinomycin is used to treat various types of cancer including testicular and sarcomas. It belongs to a group of cancer-fighting medications that inhibit the growth of cancer cells in the body.


Meractinomycin is available under the brand names Act-D and Actinomycin D and is commonly prescribed to children, but adults may also benefit from this medication. Meractinomycin is for the treatment of cancers of the soft tissue and bones particularly tendons and muscles, tumors in the womb, and cancer of the testicles.


Meractinomycin is injected in a vein for about 15 minutes. Patients are often given a medicine prior to Meractinomycin to stop any vomiting or nausea once the medication is administered.

The dosage of Meractinomycin depends on the patient’s size, blood count, condition and the cancer being treated. Blood counts are typically taken before treatment of Meractinomycin. If the lab tests indicate unsafe conditions, the treatment will be delayed.

It is typical for patients to take Meractinomycin with other chemotherapy dugs.


Meractinomycin can decrease the amount of white blood cells in the body for weeks, which can increase the patient’s risk of infection. Patients should immediately inform their doctor if they experience symptoms of an infection including high fever, pain when urinating, chills, or coughs.

Meractinomycin can lower the platelet count of the patient for a few weeks after treatment, increasing the patient’s risk of bleeding. Patients should notify their doctor if they experience unexplained bleeding including nosebleeds, tarry stools, or bleeding gums.

There is a risk that Meractinomycin will decrease the number of red blood cells in the body. Anemia, a decreased red blood cell count, often results in difficulty in breathing, and exhaustion. Your doctor may prescribe additional medicines to prevent this condition or you may need to have a blood transfusion.

Patients should not have any vaccinations while taking this medication without the prior consent of their doctor. Meractinomycin can affect a patient’s immune system and alter the effectiveness of vaccinations and can lead to severe infections.


Patients may feel sick after taking Meractinomycin so doctors usually prescribed anti-nausea medications to treat nausea and vomiting.

Meractinomycin can result in rapid hair loss. However, this is a temporary side effect and the hair normally grows back after the treatment.

Patients should talk with their doctor about their complete medical history, especially if they have had liver, kidney, heart diseases, diabetes, heart failure, gout, kidney stones, and infections. These conditions may require the dosage of Meractinomycin to be changed accordingly.

Patients who have been treated with radiation are usually given decreased dosages of Meractinomycin.


This medication can have an effect on the fertility of its users. It can cause birth defects, especially if the mother took Meractinomycin during pregnancy or conception. Patients who are taking Meractinomycin should use birth control to lessen risks of conception.

Meractinomycin has the following structural formula:

Chemical structure of meractinomycin

 Molecular formula of meractinomycin is C62H86N12O16
 Chemical IUPAC Name is 8-amino-N-(2-amino-4,6-dimethyl-3-oxo-phenoxazin-1-yl)carbonyl-N'-[8-amino-4,6-dimethyl-7-oxo-9-[[3,6,10-trimethyl-7,14-bis(1-methylethyl)-2,5,8,12,15-pentaoxo-9-oxa-3,6,13,16-tetrazabicyclo[14.3.0]nonadec-11-yl]carbamoyl]phenoxazin-1-yl]carbonyl-4,6-dimethyl-7-oxo-N,N'-bis[3,6,10-trimethyl-7,14-bis(1-methylethyl)-2,5,8,12,15-pentaoxo-9-oxa-3,6,13,16-tetrazabicyclo[14.3.0]nonadec-11-yl]-1,9-bis[[3,6,10-trimethyl-7,14-bis(1-methylethyl)-2,5,8,12,15-pentaoxo-9-oxa-3,6,13,16-tetrazabicyclo[14.3.0]nonadec-11-yl]carbamoyl]phenoxazine-1,9-dicarboxamide
 Molecular weight is 1255.42 g/mol
 Meractinomycin available : 0,5mg injection

Generic name: Dactinomycin

Brand name(s): Cosmegen, Dactinomicina, Dactinomycine, Dactinomycinum, Lyovac Cosmegen, Oncostatin K, Oxamide

  Your Meractinomycin review