is the generic name for a drug that also goes under the names of Dipyrone
, Analgin, Novalgin, and Melubrin. It is a non-opioid pain-reliever and fever-reducer that belongs to a class of medications called non-steroidal anti-inflammatory drugs, or NSAIDs. It was available all over the world from the 1920’s to the 1970’s, but at that point it was discovered that Metamizol carries with it a small risk of causing agranulocytosis, a potentially fatal condition characterized by a dangerous drop in white blood cells
. From that point, Metamizol was either banned in many countries (including Sweden, the United States, Japan, Australia, Iran, and the European Union) or restricted to being available by prescription only. However, in some places in the world, Metamizol is still available over the counter. It is used to treat pain and fever
, arthralgia, neuralgia, high fever, pain after surgeries, and other ailments that do not respond to other drugs. It is given in tablets or by injection.
Metamizol can be used for many different types of pain, including pain from different origins and various levels of intensity. Some examples include toothaches, headaches
, mild to moderate internal pain, arthralgia and neuralgia, or fever. It can also be given when other forms of treatment don’t work effectively. It is also effective for treating acute or severe pain after surgeries, as well.
The most serious side effect of Metamizol is the one mentioned above, a negative effect on the bone
marrow. It causes a decrease in the white blood
cell count, or agranulocytosis. This usually occurs on the second or subsequent use of the drug, because the body begins to build antibodies to it. Once antibodies are formed, your body can have an allergic reaction that can be fatal. Continuing to use it can be toxic to the kidneys
and produce skin rashes and asthma
. Other side effects come from the codeine
that is part of the composition of this medication, which can cause constipation
, drowsiness, and dizziness
. To counteract this, you should eat a high-roughage diet while you are being treated with Metamizol.
If you take alcohol or allergy
medications while you are taking Metamizol, they can make the sedative effects of Metamizol worse. You should also not take it if you have bronchial asthma or other breathing problems. It should always be taken after meals, because taking on an empty stomach
can make you sick, and you should avoid it if you have high stomach acid or a peptic ulcer
. Other people who should be careful about taking it include anyone with a sensitivity to any food or drugs, acute hepatic porphyria, a glucose deficiency, Quincke’s edema, or chronic lung
Metamizol should not be give to children under one year of age. No conclusive studies have been done regarding its safety on unborn babies or on nursing infant, so you should use extreme caution if you are pregnant or nursing. If you are pregnant or nursing, you should consider using a different form of pain reliever if it is available.
Metamizol has the following structural formula:
• Molecular formula of metamizol is C13H16N3NaO4S
• Chemical IUPAC Name is sodium [(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-methylamino]methanesulfonate
• Molecular weight is 333.3386 g/mol
• Metamizol available : 500mg tablets