Metoclopramide review

Metoclopramide is a drug used to relieve symptoms associated with acute and recurrent diabetic gastro paresis, documented gastro esophageal reflux disease (GERD) that cannot be treated by conventional methods. Metoclopramide is used to stimulate the upper GI tract that results in accelerated gastric emptying and intestinal transit and increased resting tone of lower esophageal sphincter. Its less common uses are: the prevention of nausea and vomiting in cancer patients receiving chemotherapy, a treatment for hiccoughs and migraines and is used to help to stimulate lactation.

Prior to taking Metoclopramide, the physician must be aware if the patient is pregnant or beast feeding. This medication carries a pregnant category of B and the drug can be excreted through breast milk. If pregnancy is expected or if it occurs, the physician should be consulted immediately. Women who are nursing or pregnant should avoid this medication.

Medication should be taken 30 minutes prior to meals and taken as direct by the health care provider. It should be noted that the drug will become more effective over a time period of 2 to 4 weeks, so the treatment should not be stopped without the knowledge of the physician. If a dose is missed or forgotten, take dose as soon as possible but do not take additional medication to make up for the missed dose. Never take more than one dose at a time. Drowsiness, irritability, disorientation, agitation, muscle hypertonia and extrapyramidal reactions are signs of overdose; if overdose is suspected seek the nearest emergency medical center or contact the poison control center.

Many people do not experience side effects when taking Metoclopramide; however the side effects that have been noted include trouble sleeping, restlessness, headache, nausea and diarrhea. Drowsiness and dizziness are side effects and caution should be taken if driving or performing actions relying on motor skills.

In rare cases, there are can be more severe side effects and if any of these should occur, the patient should contact the health care provider immediately and emergency medical treatment should be sought. Any severe allergic reactions (hives, rash, difficulty breathing and swelling of mouth, face, throat, lips or tongue), abnormal thinking, dark urine, irregular heartbeat, seizures, persistent dizziness, shortness of breath, any involuntary movements of the eyes, face or limbs, changes in libido, mental or mood changes and stiff or rigid muscles are all severe side effects of Metoclopramide.

This medication can interact with the some medications, including cisapride or droperidol (may increase occurrence of muscle rigidity, increased heart rate or mental confusion), antihistamines, narcotic pain medicines, acetaminophen, levadopa, sedatives, monoamine oxidase inhibitors, cabergoline, digoxin and peroglide. Patients should be advised never to take additional prescription or over the counter medications, herbal remedies, or vitamin supplements without first consulting with the prescribing physician.

Metoclopramide can interact poorly with several medical conditions. A thorough medical history should be assessed prior to prescribing this medication. This medication can increase blood sugar levels in diabetes patients. Extreme caution should be taken when prescribing this drug to patients with Parkinson’s disease, the elderly, patients with hypertension, and women. Metoclopramide can be a carcinogen to patients that previously diagnosed with breast cancer. Depression can occur in patients that have had previous issues with depression and in patients that never had a problem with depression. Nueroleptic malignant syndrome (NMS) is a possible fatal syndrome that can occur when taking this medication. Any signs of sweating, irregular heartbeat, confusion, abnormal thinking or mucle stiffness should report immediately to the prescribing physician.

Metoclopramide has the following structural formula:

Chemical structure of metoclopramide

• Molecular formula of metoclopramide is C14H22ClN3O2
• Chemical IUPAC Name is 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxy-benzamide
• Molecular weight is 299.796 g/mol
Metoclopramide available : 5mg tablets, 10mg tablets

Brand name(s): Cerucal, Clopra, Clopromate, Duraclamid, Elieten, Emetid, Emperal, Eucil, Gastrese, Gastrobid, Gastromax, Gastronerton, Gastrosil, Gastrotablinen, Gastrotem, Imperan, Maxeran, Maxolon, Meclopran, Metaclopramide, Metaclopromide, Metamide, Methochlopramide, Methoclopramide, Metochlopramide, Metoclol, Metoclopramida, Metoclopramidum, Metocobil, Metramid, Moriperan, Mygdalon, Neu-Sensamide, Octamide, Parmid, Paspertin, Peraprin, Plasil, Pramiel, Pramin, Primperan, Reclomide, Reglan, Reliveran, Terperan

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