, sometimes spelled Metranidazol or Metronidazole
, is the generic name of a class of antibiotics that are used to treat bacterial and parasitic infections of the abdomen, skin and tissue, bones
, infections of the respiratory tract, and gynecological infections.
Metronidazol is a prodrug, which means that its components must be activated in order for it to work. Metronidazol remains inactive until it is administered, then it metabolizes inside the body to target the organism it was meant to counteract. This type of drug design lessens the chances of Metronidazol attacking healthy cells, and improves absorption of the drug into the body.
Metronidazol (brand name, Flagyl) is effective against anaerobic bacteria, single-celled organisms that can live in environments with very little oxygen. Some examples of infections from anaerobic bacteria include bacterial peritonitis
, a disease of the abdomen; liver
abscess, and abscesses of the Fallopian tubes
. Metronidazol is also used to treat intestinal parasites like Giardia lamblia and amoeba, which cause amoebic dysentery (a colon
infection which can bring about bloody diarrhea), and vaginitis (a vaginal inflammation caused by the Trichomonas parasite).
Metronidazol gets rid of the infection by blocking the functions of the invading parasites and bacterial cells, causing them to die off. Sometimes Metronidazol is used in combination with other antibiotics for a more effective treatment.
Metronidazol is the generic name of several brands of medication. The most common of these brands are Flagyl
and Protostat. There is even a Metronidazol treatment for the skin, MetroGel
, which is used to remedy acne rosacea
(a skin infection characterized by redness and pimples), and a Metronidazol-based vaginal gel for the treatment of bacterial vaginosis (a pregnancy-related or sexually transmitted disease caused by harmful bacteria).
When your doctor gives you a prescription for Metronidazol, it is recommended that you consume the prescribed dosage according to instructions, even if you start to feel a relief from your symptoms. The reason for this lies in the fact that traces of the infection may still remain in your body and only a complete treatment will totally eradicate the bacteria and prevent it from returning.
Although Metronidazol is relatively safe to take when you are trying to fight off an infection, the drug does have accompanying counter-indications and side-effects. Alcohol should be avoided when taking Metronidazol. A combination of the two can cause flushing, palpitations, nausea
. Some cold and cough
medicines can also contain alcohol, so avoid these as well.
Inform your doctor if you have a liver disease like hepatitis, a stomach
or intestinal disorder, or if you suffer from epilepsy
or other forms of seizures before taking Metronidazol. These types of conditions may require a lower dosage or constant monitoring while you are undergoing treatment.
While Metronidazol is unlikely to harm the fetus during pregnancy, do not neglect to tell your doctor if you are pregnant. Traces of the drug may also pass into breastmilk, so it is best to inform your doctor if you are breastfeeding.
Some unpleasant but tolerable side effects of Metronidazol include dark urine, nausea or vomiting, loss of appetite
, a metallic taste in the mouth
or minor diarrhea
, or a sore tongue
. However, if you experience any allergic swelling
in your face or mouth, difficulty in breathing, seizures, numbness or tingling, dizziness
, or diarrhea, stop taking Metronidazol at once. These are symptoms of an overdose and you should seek emergency medical attention as soon as possible.
Let your doctor know if you are taking other medications that contain barbiturates, warfarin
, and lithium, as the combinations of these drugs and Metronidazol may cause dangerous side effects.
As with all other medications, your Metronidazol prescription should not be shared with anyone. It should be stored away from moisture and sunlight, and not be left where children can find them.
Metronidazol has the following structural formula:
• Molecular formula of metronidazol is C6H9N3O3
• Chemical IUPAC Name is 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol
• Molecular weight is 171.154 g/mol
• Metronidazol available : 750mg tablets, 0.75% cream 45gm tube, 0.75% lotion 59ml bottle, 250mg tablets, 500mg tablets