Minims atropine
Minims atropine

Minims atropine review

Minims Atropine is a tropane alkaloid obtained from Atropa belladonna (deadly nightshade), Datura stramonium (jimsonweed), Mandragora officinarum (mandrake), and other plants of the family Solanaceae. This versatile medicament is a secondary metabolite of the above plants and provides a variety of effects and uses. Classified as an anticholinergic medicament, it serves as a competitive antagonist for the muscarinic acetylcholine receptor. Also known as Atropen, this medicament derives its name from Greek Mythology and is named after Atropos, one of the three Fates.

On The World Health Organization's Essential Drugs List (a list of minimum medical requirements for a basic healthcare system), Minims Atropine is considered a core medicine to any healthcare system.

Adult doses vary from half a milligram to one milligram or five to ten milliliters of the 0.1 milligram/milliliter solution for antisialagogue and other antivagal effects, add two to three milligrams or twenty to thirty milliliters of the 0.1 milligram/milliliter solution as an antidote for organophosporous muscarinic poisoning.

When no IV is available, patients should use the endotracheal administration of Minims Atropine. One to two milligrams diluted to a total of no more than ten milliliters of normal saline or sterile water is the suggested adult dose of Minims Atropine for endotracheal administration. Dosage intervals of one or two hours are recommended for cases that are not serious or critical.

Special consideration must be given to all patients over forty years of age when giving Minims Atropine Sulfate Injection (USP). Acute glaucoma may occur during Minims Atropine treatment in susceptible patients. Patients with prostatic hypertrophy may develop complete urinary retention, convert partial organic pyloric stenosis into complete obstruction, or cause inspissation of bronchial secretions and formation of dangerous viscid plugs in patients with chronic lung disease. Due to these potentially dangerous conditions, you must make certain that your physician is aware of your complete medical history before beginning any treatment with Minims Atropine.

Since recurrent use of Minims Atropine is crucial in patients suffering from coronary artery disease, the total dose needs to stay at or below two to three (maximum 0.03 to 0.04 milligrams/kilograms) to prevent the harmful side effects of Minims Atropine-caused tachycardia on myocardial oxygen demand.

Patients with bradyasystolic cardiopulmonary arrest should be given a single milligram dose of Minims Atropine intravenously and repeated every three to five minutes until symptoms subside. Three milligrams (0.04 milligrams/kilograms) given intravenously is a sufficient vagolytic dose in most patients. Note that the administration of less than 0.05 milligrams can produce a paradoxical heart slowness because of the peripheral or central parasympathomimatic effects of low dose Minims Atropine in some adults.

When being used as an antidote, Minims Atropine's two to three milligram dose should be repeated no less than every twenty to thirty minutes until symptoms are significantly reduced or until signs of Minims Atropine poisoning occur. Typically, the initial dose of this medicament is usually around 0.01 to 0.03 milligrams/kilograms of body weight. Dosing information for children hasn't been well researched. This medicament should not be used on a child without consulting with a physician first.

Side effects include tachycardia, photophobia, blurred vision, and dryness of mouth. These symptoms commonly occur with chronic therapeutic doses. For patients living in a hot climate, Anhidrosis (heat intolerance) and impaired temperature regulation may occur. Urination difficulties and constipation may be experienced by elderly patients. Occasional hypersensitivity, rashes, and exfoliation have also been reported. If you experience any of these symptoms, consult your physician.

Side effects due to Minims Atropine poisoning include ataxia, fatigue, tremor, restlessness, dizziness, thirst, hot and dry skin, difficulty swallowing, dilated pupils, and abnormality of heartbeat. In some cases, it may lead to coma, delirium, hallucinations, restlessness and excitement, and marked abnormality of heartbeat. Severe intoxication while taking Minims Atropine can lead to circulatory collapse and depression. Due to this, patients are advised to avoid alcohol consumption altogether while taking this medicament. Seek immediately medical attention if you experience any of these symptoms.

Minims atropine has the following structural formula:

Chemical structure of minims atropine

• Molecular formula of minims atropine is C17H23NO3
• Chemical IUPAC Name is (8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenyl-propanoate
• Molecular weight is 289.369 g/mol
Minims atropine available : 5ml 1% bottles

Generic name: Atropine

Brand name(s): Atnaa, Atropair, Atropen, Atropin, Atropina, Atropinol, Atropisol, Atrosulf, Equipin, Eyesules, Hyoscyamine, I-Tropine, Isopto atropine, Minims atropine, Ocu-Tropine, Tropine tropate, Troyl tropate

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