Minoxidil review

The drug minoxidil is known as a vasodilator medication, which is very well known for its ability to stop hair loss and promote regrowth.

Minoxidil has first been introduced as an oral drug for the treatment of high blood pressure. However, it had a rather different side effect – reversing the balding process. Then, a topical solution was made which contained 2% of minoxidil for women, and 5% for men.

Minoxodil is widely known as Rogaine, or Regaine. This drug is available as an over the counter drug, in the form of gel applied to the balding area of the scalp. Minoxidil is primarily indicated in the treatment of baldness in men, and thinning of hair in the scalp for women.

Minoxidil is applied as 1 mL of a solution, or half of it, to dry hair and dry scalp twice a day, one in the morning and the other at night. Minoxidil is recommended for use at least twice a day and four months the least to expect results. The drug works less in patients who have been bald for a long period.

The most commonly reported side effects of the drug include irritation of the skin manifested by itching, contact dermatitis and the flaking of the scalp. Minoxodil solutions contain alcohol that may be harmful to the eyes.

The drug is contraindicated in patients with a known hypersensitivity to the drug or its known components, as it may increase the risk of the patients.

It is not known whether glycopyrrolate has adverse effects to the fetus. However, the use of the drug in pregnant women should always be consulted with the doctor. Minoxidil was found excreted in breast milk, albeit at a very little amount. However, nursing mothers, or women planning to breastfeed must first consult their doctor prior to the usage of the drug. The potential benefits of the drug must always be weighed against its risks to the nursing mother and infant.

Minoxidil has the following structural formula:

Chemical structure of minoxidil

• Molecular formula of minoxidil is C9H15N5O
• Chemical IUPAC Name is 3-hydroxy-2-imino-6-(1-piperidyl)pyrimidin-4-amine
• Molecular weight is 209.248 g/mol
Minoxidil available : 2.5mg tablets and 10mg tablets

Brand name(s): Alopexil, Alostil, Apo-Gain, Gen-Minoxidil, Loniten, Lonolox, Minodyl, Minossidile, Minoxidilum, Minoxigaine, Minoximen, Normoxidil, Pierminox, Prexidil, Regaine, Rogaine, Theroxidil, Triclosan, Tricoxidil, Trocoxidil

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