Moclobemide review

Moclobemide is one useful antidepressant drug. It proves to render very effective results but people also need to watch out for possible side effects through safe and proper intake.

Moclobemide is the generic name of the psychiatric or antidepressant drug which also comes under the brand names Manerix and Aurorix. It is primarily used to treat depression and social anxiety and first surfaced in 1977. The United States do not have the drug commercially available and stocks usually come from Canada. Treatment of depression is described as major according to DSM-III while social anxiety disorder treatment is used in conjunction with cognitive-behavioral therapy. Moclobemide belongs to the MAOI drug class or monoamine oxidase inhibitors.

As an antidepressant, the drug is used to relieve symptoms and types of mental depression by blocking the chemical monoamine oxidase which is present in the nervous system. Moclobemide usually comes in tablet form which should be taken orally. Approximately one out of every five people experiences depression at varying degrees during their lifetime as evidenced by a number of symptoms. The duration may also last depending on the severity and response of the patient. The drug is used to normalize chemicals responsible for mood. People should know that it is not a tranquilizer or sleeping agent.

Just like all antidepressant medications, Moclobemide can cause a variety of side effects at different degrees. Common symptoms include mild or moderate headache, pressure in the head, dry mouth, shaking or trembling of arms and legs, insomnia, dizziness, nausea, diarrhea or constipation, agitation and insomnia. Less common symptoms include anxiety, extreme dizziness, blurred vision or double vision, faintness, lightheadedness when rising from a lying or sitting position, slow, fast, irregular, racing or pounding heartbeat, high blood pressure, frequent irritability, nervousness, throbbing headache radiating from the back of the head to the front and neck pain and stiffness.

Rare symptoms should immediately be reported to a doctor such as aggressive behavior, bleeding gums, burning or tingling sensations, chest pain, increased depression, confusion, mood or mental changes, mouth soreness, hallucination, ringing in the ears, painful urination, eye swelling, prolonged menstrual periods, photosensitivity, uncontrollable movements of the body, face and neck and loss of balance. It is also possible to have Moclobemide overdose as evidenced by seizures, loss of memory, vomiting, slurred speech and decreased reflexes.

Contraindications for Moclobemide include hypersensitivity reaction to the drug, patients with hepatic disease, individuals under 18 years of age, confused patients, those using sympathomimetic, MAOIs, meperidine, serotonergic and tricyclic antidepressant drugs. Moclobemide should not be taken by those who have discontinued taking antidepressants within 2 weeks or fluoxetine within 5 weeks. Other precautions include people with renal impairment, pheochromocytoma, Parkinson’s Disease and thyroid dysfunction. Watch out for those taking buspirone, sedatives and anesthesia.

A study was conducted on 18 patients clinically diagnosed with severe depression. The group was treated with 300 mg everyday divided into 2 or 3 doses for 1 week. For the second week, dosage was increased to 400 mg. From the fourth up to the sixth week, total dosage was 600 mg daily. At the end of the study, 12 patients exhibited significant improvement in depressed state. Only 6 showed moderate side effects.

Moclobemide acts on epinephrine, norepinephrine, dopamine and serotonin to enhance mood. As a benzamide derivative, the drug acts as a short-acting reversible inhibitor of the chemical monoamine oxidase which in turn controls serotonin, norepinephrine and dopamine metabolism leading to improvement in mood and depressed state.

The drug is available at pharmacies and online drugstores but requires a doctor’s prescription. Make sure that the manufacturer is legitimate and check product freshness through the indicated expiry date.

Only take Moclobemide as recommended by the doctor. 300 mg divided into 2 to 3 doses daily is the usual recommendation but more severe cases of depression and social anxiety may reach up to 600 mg daily. Do not abruptly stop taking the medication unless indicated.

Moclobemide has the following structural formula:

Chemical structure of moclobemide

• Molecular formula of moclobemide is C13H17ClN2O2
• Chemical IUPAC Name is 4-chloro-N-(2-morpholin-4-ylethyl)benzamide
• Molecular weight is 268.7393 g/mol
Moclobemide available : 300mg tablets

Brand name(s): Aurorix, Manerix, Moclaime, Moclamide, Moclamine, Moclobemid, Moclobemida, Moclobemidum

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