, an immunosuppressant used to weaken the immune system, also goes by the brand names Muran and Azasan
. Available in tablet form, as an injection, or intravenously, Muran is administered to patients anticipating an organ transplant or who have been given a new organ, to help prevent rejection by the immune system. This medicament is also prescribed to reduce the signs and symptoms of rheumatoid arthritis
. Muran is also administered to treat colitis ulcerosa. Other inflammatory conditions can be treated by Muran. These include systemic lupus erythematosus, inflammatory myositisis, inflammatory bowel disease, and vasculitis
. Symptoms usually improve in six to eight weeks, though it can sometimes take up to twelve weeks.
Muran's most important side effect to note is that it can cause a decrease in the number of blood cells
in your bone
marrow. Contact your healthcare professional immediately if you experience any unusual bleeding or bruising, fatigue, headache
, increased heart
rate, weakness, difficulty breathing, sore throat, pyrexia, chills, or any signs of infection. This medicament can increase your risk of developing some cancers, like skin cancer
. Inform your healthcare professional if you have ever taken any cancer medicaments or if you find any suspicious lumps or masses on your body.
Common side effects include an upset stomach
, emesis or diarrhea
, muscle soreness, blurred vision, mouth
sores, coughing, lack of energy or appetite, flu-like symptoms, rash, or yellowing of the skin or eyes. Consult your healthcare professional if these symptoms are severe or persist. While taking Muran, have regular blood
tests done to ensure that these side effects are not inhibiting your treatment. Some patients cannot take Muran, or may require a lower dosage or special monitoring to undergo treatment.
If you are pregnant or may become pregnant, discuss the benefits and risks of this medicament with your healthcare professional. Studies on the effects of Muran offer contradicting conclusions with respects to the safety for pregnant women. Early studies indicated Muran would not cause any deformities or issues for a developing fetus, and seemed to pose very little risk for pregnant women or their babies. Recent studies suggest that harm to the fetus can result from taking Muran. No conclusions have been reached regarding how much harm or what levels of treatment put a fetus in danger. It is always best to err on the side of caution. Due to the uncertainty, exercise extreme caution if you are pregnant and considering treatment with Muran. Do not breastfeed while taking this medicament. It is a cytotoxic medicament and can be harmful to nursing babies.
Muran has the following structural formula:
• Molecular formula of muran is C9H7N7O2S
• Chemical IUPAC Name is 6-(3-methyl-5-nitro-imidazol-4-yl)sulfanyl-7H-purine
• Molecular weight is 277.264 g/mol
• Muran available : 50mg tablets