Nateglinide review

Type 2 diabetes mellitus can finally be controlled with Nateglinide. The drug offers potent effects when used singly or together with other anti-diabetic medications.

Nateglinide is the generic name of the diabetes drug mainly used to control blood sugar levels. It also comes under the brand name Starlix developed by Novartis to specifically treat type 2 diabetes mellitus or non-insulin dependent diabetes mellitus or NIDDM when hyperglycemia cannot be alleviated only by exercise and diet. Nateglinide belongs to the blood glucose-reducing drug class called meglitinide.

The drug helps the body regulate the amount of glucose in the blood as well as respond better to insulin which is normally produced by the pancreas. Nateglinide comes in 60 mg or 120 mg tablets which should be taken orally. The medication can be used in monothereapy for NIDDM or in conjunction with other anti-diabetic drugs like thiazolidinedione or metformine. It cannot however, be used as a substitute for these drugs. Nateglinide cannot cure but can help alleviate the variety of symptoms associated with NIDDM. By lowering blood sugar levels, it can also prevent strokes and heart, cardiovascular and kidney disease.

Nateglinide can cause different side effects such as shakiness, lightheadedness or shakiness, sweating, irritability or nervousness, headache, numbness or tingling sensation around the mouth, body weakness, pale skin, hunger, jerky movement, sudden mood or behavioral changes, seizure, loss of consciousness and confusion. It can also trigger hyperglycemia symptoms such as frequent urination, extreme hunger, body weakness, blurred vision and extreme thirst. Seek medical attention if these symptoms are present: dry mouth, upset stomach, vomiting, diarrhea, sudden weight gain, urticaria, arthropathy fruity breath, reduced consciousness, shortness of breath, nasal congestion, joint pain, back pain, constipation, cough, flu-like symptoms and jaundice.

Patients with known hypersensitivity reactions to the drug are contraindicated as well as those with diabetic ketoacidosis with or without coma and type 1 diabetes mellitus or insulin dependent diabetes mellitus or IDDM. Special precautions are given to those with gout, hepatic impairment, severe renal dysfunction, the elderly, the malnourished, adrenal or pituitary dysfunction, pregnant women and lactating mothers. Nateglinide may also interact with drugs like corticosteroids, other NSAIDs, diuretics, ephinephrine, oral contraceptives, thyroid medications, herbal products and beta-blockers.

Nateglinide is a phenylalanine derivative and non-sulfonylurea hypoglycemic agent that acts by stimulating insulin release from the beta cells of the pancreas. The amount of insulin produced is dependent on the amount of glucose available. The resulting effect would be reduced postprandial hyperglycemia that can control type 2 diabetes mellitus.

A 24-week study involved 402 type 2 diabetic patients who were treated either with 120 mg of Nateglinide before meals or a placebo added to 8 mg of rosiglitazone monotherapy. Prior to the study, all patients were diagnosed of NIDDM at least 6 months before and have had rosiglitazone monotherapy, exercise and diet for at least 3 months. Results showed that patients who received Nateglinide were significantly in a much better state compared to the placebo group resulting to the conclusion that the drug is truly effective when used independently or together with others like metformin.

Nateglinide is commercially available in doctors’ clinics, pharmacies and online drugstores. When buying online, make sure that the source and manufacturer are legitimate by asking for verification or online certification provided to legal internet drugstores. Find out the address and contact numbers as well.

The usual dose for Nateglinide is 3 times daily around 30 minutes before meals. Make sure you do not double the dosage if you happen to skip. Wait for your next meal to take the next dose. Be cautious about hypoglycemia by eating well, minimizing or avoiding alcohol and exercising right. Take the drug regularly to reap maximum benefits and monitor blood sugar levels constantly.

Nateglinide has the following structural formula:

Chemical structure of nateglinide

• Molecular formula of nateglinide is C19H27NO3
• Chemical IUPAC Name is 3-phenyl-2-(4-propan-2-ylcyclohexyl)carbonylamino-propanoic acid
• Molecular weight is 317.423 g/mol
Nateglinide available : 60mg tablets

Brand name(s): Fastic, Starlix, Starsis

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