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Neo-Mercazole

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Neo-Mercazole

Neo-Mercazole review





Neo-Mercazole, an imidazole antithyroid agent, converts to methimazole after being absorbed by the body, which generates an antithyroid action that works against hyperthyroidism (excessive production of thyroid hormones) and thyrotoxicosis (inflammation of the thyroid gland).

Neo-Mercazole is available by various brand names, including Atirozidina, CG1, Neo-Theyreostat, Neo-Tireol, Neomercazole and Tyrazol. This medication is most often used for hyperthyroidism, when preparing a patient for thyroidectomy (surgical removal of all or part of the thyroid gland), and together with radio-iodine therapy for hyperthyroidism.

Hyperthyroidism occurs when the thyroid gland produces an excess amount of T3 (triiosdothyronine) or T4 (thyroxine) hormones. Thyroid hormones regulate metabolism, so too many thyroid hormones in the body will speed up metabolism, including the digestion and cardiovascular functions. Symptoms include palpitations, intolerance for heat, insomnia, breathing difficulties, frequent bowel movement, fatigue, weight loss, warm moist skin, muscle weakness, hair loss, trembling hands, and light or absent menstrual periods.

Iodine is a basic element in the formation of thyroid hormones. Neo-Mercazole works by preventing iodine from binding with other components to form thyroid hormones. This decreases thyroid function by reducing the thyroid gland's production of thyroid hormones. The effects of this medication are usually noticed three to four weeks after treatment begins, because the body will need to use up the thyroid hormones already existing before the medication was started.

Patients with hyperthyroidism need to tell their healthcare professional if they are allergic to Neo-Mercazole or any of its ingredients. If patients experience any allergic reactions, the medication should be stopped until they can consult their healthcare professional. Patients who are pregnant should use Neo-Mercazole with extreme caution and only if the benefits of taking the medication outweigh the risks to their unborn child. Since Neo-Mercazole passes into breast milk, breastfeeding is not recommended while taking this medication as it might harm the nursing infant.

Known side effects include headaches, pruritus (itching), nausea, blood disorders, diarrhea, constipation, nausea, vomiting and stomach aches, myalgia (muscle pain), arthralgia (joint pain), jaundice (yellowing of the skin), hair loss, and a skin rash.

A serious side effect involves a decrease in the bone marrow's production of blood cells, also known as bone marrow suppression. If this is accompanied by signs of an infection including a fever, a sore throat or mouth ulcers, the condition requires immediate medical attention.

If other side effects that are not listed here develop, consult your healthcare professional immediately.

Neo-Mercazole is available in pink, circular 20 and 5 mg. tablets. Healthcare professionals often prescribe a gradually reduced dosage, giving just enough medication to control the condition. Higher dosages may result in an enlargement of the thyroid gland.

Neo-mercazole has the following structural formula:

Chemical structure of neo-mercazole


• Molecular formula of neo-mercazole is C7H10N2O2S
• Chemical IUPAC Name is ethyl 3-methyl-2-sulfanylideneimidazole-1-carboxylate
• Molecular weight is 186.2315 g/mol
Neo-mercazole available : 20mg tablets

Generic name: Carbimazole

Brand name(s): Athyromazole, Atirozidina, Basolest, Carbethoxymethimazole, Carbimazol, Carbimazol Spofa, Carbimazolum, Carbotiroid, Mertiran, Neo-Thyreostat, Neo-Tireol, Neomercazole, Tyrazol

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