Neoral review

Neoral is an immunosuppressive medicament with its most popular use being combating organ rejection for patients who just had an organ transplant - skin, pancreas, small intestine, kidney, lung, heart, and bone marrow. By suppressing the activity of the immune system, Neoral helps the replaced organ work with the body's system.


Discovered in the early 1970s, Neoral made transplants possible without increased risk of morbidity. The medicament was first intended for antimicrobial use. When its immunosuppressive properties were recognized, immunological tests and investigations were quickly initiated. The first successful use of Neoral with an organ transplant patient occurred on March 9, 1980. Three years later, in 1983, Neoral was approved for clinical use.

Aside from its role in transplants, Neoral is also effective as a interposition for Psoriasis, Rheumatoid Arthritis, and Atopic Dermatitis. It has also been found useful in protecting patients from brain damage. Neoral as a interposition for Psoriasis is found to be the safest and quickest interposition with very mild side effects, especially when used for a short period of time.


Neoral is available in capsule and liquid suspension to be taken orally twice a day. The dosage requirement is different for every patient. Some of the factors that determine the prescription include the patient's condition, blood pressure, weight, and how well their kidneys are working. At any point within the medicament period, the medico may adjust the dose depending on the patient's response to the medicament. Normally, patients who are being treated with Neoral are required to take blood tests every so often. This is to monitor the levels of the medicine obtained in the blood. It is advisable that you take Neoral after the blood test. If you missed a dose, take it as soon as you realize it. However, if the missed dose is too close to the next scheduled dose, it is better that you discard the missed dose and proceed with your normal dosing schedule.


As mentioned above, Neoral is found to be very effective with mild side effects. Some of the mild side effects that are usually experienced by patients who are taking it for a short period include headache, nausea, joint pain, and gum swelling. Neoral can also elevate the patient's cholesterol and triglycerides level as well as blood pressure. It is important that you be closely monitored by your medico while undergoing Neoral interposition.


There are a couple of precautions you need to take while undergoing Neoral interposition to be on the safe side. Do not take any new medicines without the knowledge of your medico. Medication interactions may cause damage to your health; it can even be fatal. So it is important that you take extra care. Also, you must not have grapefruit or grapefruit juice while taking Neoral. Grapefruit interferes with the levels of Neoral obtained in your blood.

Always wait for your medico's instructions. Do not stop or continue taking the medicine without your medico's advice. Also, take note of the physical discomfort that taking the medicine brings. Persistence of side effects, especially if it is greater than the benefits that you get from the medicament, must be taken to your medico's attention.

Neoral has the following structural formula:

Chemical structure of neoral

 Molecular formula of neoral is C62H111N11O12
 Chemical IUPAC Name is 30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methyl-hex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-dipropan-2-yl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
 Molecular weight is 1202.61 g/mol
 Neoral available : 25mg capsules, 100mg capsules

Generic name: Cyclosporine

Brand name(s): Gengraf, Restasis, Sandimmune

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