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Nilutamide

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Nilutamide

Nilutamide review





As an anti-androgen medication known under the trade names of Anandron in Canada and Nilandron in the United States, nilutamide is quite the useful drug best administered in advanced-stage prostate cancer therapy. It works by preventing the androgen receptor from interacting with testosterone by blocking its path.

The drug is supplied in boxes of thirty tablets that contain child-proof, aluminum foil-backed blisters for every ten tablets. The tablets themselves are biconvex, cylindrical (ten millimeters in diameter), and white, with each sporting an internal reference number on one side and a triangular logo on the other.

As indicated in its description, nilutamide is best taken by patients suffering from advanced-stage prostate cancer. Bearing in mind it's mechanism of action (androgen receptor blockage to stop testosterone interaction), the drug could conceivably lengthen the life of prostate cancer sufferers because the majority of prostate cancer cells depend on the testosterone-based stimulation of the androgen receptor for survival and development.

Three hundred milligrams once daily is the recommended dosage for nilutamide, although half that dose every day can be given as well depending on the prescription. Nilutamide tablets for either Anandron or Nilandron can be swallowed with or without food.

Nilutamide is known to potentially cause side effects that range from minor to grave. For instance, symptoms of visual disturbances may occur, the most notable of which is lengthened visual adaptation time when moving from a brightly lit place to a more dimly lit area; your eyes need a longer time to adjust themselves to the dark than normal. This symptom is mostly fleeting and wearing tinted glasses usually helps.

Furthermore, the far more serious side effect of getting respiratory diseases may also happen—particularly interstitial lung disease. Indigestion can act as a symptom of this condition as well. Watch out for liver problems that include tenderness above the navel and the right side of your abdomen, itching, vomiting, nausea, dark urine, and persistent lack of appetite. Hot flushes can also occur because nilutamide is a testosterone hormone blocker.

Nilutamide's influence on the liver extends to interacting with the drugs that are metabolized by this organ. By hampering your liver's function, you tend to get higher levels of the aforesaid drugs into your body, which can include diazepam, theophylline, lidocaine, chlordiazepoxide, propranolol, phenytoin, and anticoagulants or blood thinners. Moreover, the drug can cause the disulfiram reaction (which involves vomiting and nausea) by interacting with alcohol.

Before taking this medicine, consult with your healthcare specialist and tell him if you are allergic to this medication, any other medications, foods, additives, and dyes. You must also tell him if you have diseases and conditions like infections, gout, diabetes, congestive heart failure, heart disease, liver disease (including hepatitis), lung or respiratory problems, and kidney disease. Such maladies can compel your doctor to adjust your nilutamide dosage, timing, and regimen.

You should also be cautious of taking this drug if you are (or if you're attempting to be) pregnant. This drug has been reported to potentially cause birth defects if either parent is taking it from the time of conception to the middle of pregnancy.

Nilutamide has the following structural formula:

Chemical structure of nilutamide


• Molecular formula of nilutamide is C12H10F3N3O4
• Chemical IUPAC Name is 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
• Molecular weight is 317.221 g/mol
Nilutamide available : 150mg tablets

Brand name(s): Anandron, Nilandron, Nilandrone, Nilutamida, Nilutamidum

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