Nimodipine review

Brain damage can be prevented by Nimodipine which has more specific actions towards cerebral arteries. Find out more about the beneficial and consequential effects.

Nimodipine is the generic name of the dihydropyridine calcium channel blocker which is used to treat high blood pressure. It also comes under the brand name Nimotop developed by Bayer. The drug can treat symptoms from a ruptured brain blood vessel or aneurysm by boosting blood flow to injured tissues in the brain and as a result prevents brain damage. It can prevent big complications from subarachnoid hemorrhage or vasospasm. There are also other uses for the drug which are unlabeled. Nimodipine usually comes in the form of tablet which should be taken by mouth.

Nimodipine also causes a variety of side effects just like any other drug such as headache, dizziness, lightheadedness, heartburn, fast or irregular heartbeat, stomach pain, constipation, diarrhea, flushing, depression, unusual bleeding or bruising, slow heartbeat, swelling in the lower extremities, fainting, severe dizziness, mild dizziness, nausea, sweating and tingling sensations. Allergic reactions include difficulty breathing, hives, rash, chest tightness, mouth, tongue, face or lip swelling, black or bloody stools and jaundice. Other symptoms may also be present so patients should seek medical attention immediately upon noticing adverse effects.

Patients who are suffering from hepatic disease, intestinal pseudo-obstruction, hypersensitivity reaction and increased intracranial pressure may be prohibited from taking Nimodipine. Special precautions are given to pregnant women, nursing mothers and those with a history of bowel obstruction and reduced GI motility. Those with extremely low blood pressure, fluid in their lungs, history of heart attack, heart problems and kidney disease should also take the drug with caution and doctor’s advice. Doctors should be fully informed about the patient’s underlying conditions and current ingestion of herbal medications, other drugs and supplements to prevent adverse interactions.

A clinical trial involving 46 patients was done wherein half of the patients received 30 to 90 mg of Nimodipine every 4 hours for a duration of 3 weeks. The rest were given a placebo. All patients were considered as having recent SAH or subarachnoid hemorrhage. At the end of the study, the Nimodipine group should significantly fewer deficits compared to the placebo group. Researchers then concluded that Nimodipine is a highly effective calcium channel blocker that can improve brain blood flow.

As a calcium channel blocker, Nimodipine stops calcium ions from entering the slow channels or choose voltage-sensitive areas of the myocardium and smooth muscle during depolarization. As a result, blood flow is enhanced to injured areas specifically in the brain to prevent damage. Nimodipine is more specifically useful on cerebral arteries compared to others because of its higher lipophilicity and cerebral distribution.

Nimodipine is readily available in most drugstores, online pharmacies and clinics although some may require a doctor’s prescription before releasing. Getting stocks online may be cheaper and more convenient but you have to check for proper certification by finding out the legal source, manufacturer and address. You may contact the numbers provided to ensure that it exists and is legitimate.

The usual dose for adults is around 60 mg every 4 hours for 3 weeks. Therapy is started within 4 days after subarachnoid hemorrhage. Patients should not double the dose. If a dose is missed, they may choose to skip it altogether and take the next one indicated. Make sure to store Nimodipine in a tightly sealed container away from sunlight, moisture and children’s reach.

Nimodipine has the following structural formula:

Chemical structure of nimodipine

• Molecular formula of nimodipine is C21H26N2O7
• Chemical IUPAC Name is 2-methoxyethyl1-methylethyl2,6-dimethyl-4-(3-nitrophenyl)-1, 4-dihydropyridine-3,5-dicarboxylate
• Molecular weight is 418.44 g/mol
Nimodipine available : 30mg tablets

Brand name(s): Nimodipino, Nimodipinum, Nimotop, Periplum

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