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Nisoldipine

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Nisoldipine

Nisoldipine review





Nisoldipine which is also known by the trade name of Sular is a calcium-channel blocking agent developed specifically for high blood pressure treatment. The propriety tablet itself is an extended release sort of medication containing a yellowish crystalline substance that's just about water insoluble yet ethanol soluble.

It has an outer coat that's slow-release formulated and an inner core that's fast-release formulated, with both containing trace amounts of nisoldipine. Furthermore, the medication comes in four dose variations: ten, twenty, thirty, or forty milligrams of nisoldipine for daily oral therapy.

People who have high blood pressure problems, heart conditions, and other related diseases should take this drug. It works by influencing movement of calcium into the cells of blood vessels and the heart itself. It also makes blood vessels relax and dilate as well as increase the supply of oxygen and blood to the heart while alleviating its workload.

The recommended dose of nisoldipine hinges mostly on the patient himself. You may be prescribed ten, twenty, thirty, or forty milligrams worth of once-a-day oral dosages, but it can be also adjusted by your doctor in the middle of therapy in accordance to your individual requirements. Blood pressure response can also influence your doctor to increase your dose from ten to sixty milligrams daily, but adverse event rates can also go on the rise during such increases.

Patients are typically initiated with twenty milligrams of tablets taken orally once a day, with the dose gradually increased by ten milligrams every week or longer depending on your doctor's judgment and how well your body is reacting to the medication. As for the usual maintenance dosage, it ranges from twenty to forty milligrams once daily.

The most common side effects associated with nisoldipine is sore throat, headache, dizziness, swelling or water retention, heart palpitations, flushing, and nausea. The other usual side effects are mostly rooted on anything related to the drug's vasodilator properties. These are mostly mild and not serious enough to kill patients, although withdrawing from further treatment if such symptoms persist is an occasional occurrence.

Serious but rarer nisoldipine side effects include depression, signs of an allergic reaction (for example, difficulty in swallowing or breathing, wheezing, inexplicable swelling, itching, hives, and unexplained rash), severe swelling, water retention, diabetes, signs of low blood pressure (for example, lightheadedness and dizziness followed by fainting), stroke, heart attack, arrhythmia or irregular heart rhythm, and chest pain. Report these symptoms immediately to your healthcare specialist.

Before taking nisoldipine, you must first tell your nurse, doctor, or pharmacist if you've ever had any allergic or strange reactions to this drug or any other calcium channel blocking medication under the dihydropyridine family. Moreover, your medical specialist must be the first one to know if you're allergic to any other drugs or substances, namely dyes, preservatives, foods, or dust.

Nisoldipine's effects on expecting mothers have unfortunately not been studied. Then again, animal tests have shown that, in very high doses, the medication can cause fetal death. Before taking nisoldipine, inform your doctor immediately if you could become pregnant or are already pregnant.

In terms of drug interactions, it's always best to tell your physician beforehand of any other prescription or nonprescription medications you're taking (even something as simple as multivitamins or over-the-counter cold medicine) so that he could make the necessary nisoldipine dose adjustments and other precautions as necessary.

Nisoldipine has the following structural formula:

Chemical structure of nisoldipine


• Molecular formula of nisoldipine is C20H24N2O6
• Chemical IUPAC Name is methyl2-methylpropyl2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• Molecular weight is 388.414 g/mol
Nisoldipine available : 10mg tablets, 20mg tablets, 30mg tablets and 40mg tablets

Brand name(s): Baymycard, Nisocor, Nisoldipin, Nisoldipino, Nisoldipinum, Sular, Syscor, Zadipina

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