Nitalapram review

Nitalapram is one of the most effective anti-depressants ever produced. Created in 1989, it paved the way for other companies to produce generic versions upon the expiration of its patent in 2003. One of them is the known as Cipralex or Lexapro with Forest Laboratories as the manufacturers of the medication who acquired the license rights from Forest Lundbeck. They are manufactured in Denmark.

Formulated to treat the symptoms of depression, it was also the preferred medicine to cure a lot of other illnesses including social anxiety disorder panic disorder or obsessive-compulsive disorder. This medication is also prescribed for Huntington's disease and premenstrual dysphoric disorder.

It's also being tested for other uses that are yet to be officially approved, including the significant reduction of symptoms of diabetic neuropathy and premature ejaculation. Some claim evidence that Nitalapram might be effective for the treatment of post-stroke pathological crying. Taken alone, it is a slightly more effective treatment than amitriptyline for the prevention of migraines, in refractory cases combination therapy may be more effective.

Though Nitalapram is considered generally safe and well tolerated with a dose range of 20 to 60 mg a day, constant monitoring by the doctor is required. Pretty distinct from the others of its class, it exhibits linear pharmacokinetics and minimal medication interaction. This makes it the better choice for the elderly or comorbid patients. However, Nitalapram should always be taken with caution.

According to a study with clinical trials, it was reported that over 10% of patients reported adverse reactions such as languidness, drowsiness, xerostomia, increased sweating (hyperhidrosis), trembling, headache, dizziness, sleep disturbances, insomnia, cardiac arrhythmia, blood pressure changes, wamble and/or vomiting, diarrhea, heightened anorgasmia in females, and impotence and ejaculatory problems in males. There were even rare cases (around 1% of cases), which displayed allergic reactions, convulsions, mood changes, anxiety and confusion.

Another side effect is sedation that may be may be present while under treatment with Nitalapram. Should this happen, it is advisable to take the dose at bedtime instead of in the morning.

A unique side effect is bruxism (teeth grinding). Upon starting the treatment, patients may experience a feeling similar to electricity or minor shocks in their upper body and in their hands. It was concluded that the chemical changes occurring in the brain is the cause of this. There might also be panic attacks or thoughts of suicide or self-injury, which might increase in the first few weeks, before the antidepressant effect starts.

As far as sexual side effects are concerned, it was reported to affect both males and females. Usually reversible, it can last for months or years after the medication has been completely withdrawn with the disorder known as Post SSRI Sexual Dysfunction.

Nitalapram has the following structural formula:

Chemical structure of nitalapram

• Molecular formula of nitalapram is C20H21FN2O
• Chemical IUPAC Name is 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
• Molecular weight is 324.392 g/mol
Nitalapram available : 60mg tablets

Generic name: Citalopram

Brand name(s): Celexa, Cipram, Cipramil, Citalopramum

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