Norethindrone review

Norethindrone , marketed as Aygestin, contains a type of hormone identified as progesterone, which is used to restore menstruation in women who have stopped having menstrual cycles or periods (also called amenorrhea). Norethindrone can also assist in treating endometriosis, a malady wherein the lining of the uterus or the endometrium doesn't shed properly and attaches to the outside of the uterus or other areas such as the bowels or ovaries. Furthermore, this drug can manage heavy and unusual uterine bleeding caused by an imbalance of your hormones. Nevertheless, it should not be used to control fibroid-type or cancerous bleeding.

The recommended dose for abnormal uterine bleeding caused by hormonal imbalance or for restoring menstrual periods is 2.5 to 10 milligrams daily taken for five to ten days during the second half of the twenty-eight day cycle. Your period should begin three to seven days after you stop taking this medication.

As for endometriosis therapy, the advised beginning dose is five milligrams daily for fourteen days. Your doctor may increase your dose by 2.5 milligrams a day for fourteen days up to a maximum of fifteen milligrams a day depending on the severity of your condition. Norethindrone therapy may continue for six to nine months or until unbearable breakthrough bleeding happens.

Keep in mind that norethindrone can increase your risk for clot-related disorders. Consult your healthcare specialist promptly if you experience any of the symptoms listed in the side effects section of this drug review. Your doctor will probably give you a complete physical exam including examination of your breasts and pelvic organs in order to rule out cancer and other problems before you start taking norethindrone . You should also take a Pap test or cervical smear test as well.

Norethindrone can cause some degree of water retention, so if you have a medical condition that may become worse because of water retention—for example, asthma, heart or kidney problem, migraine, or epilepsy—you should report it to your doctor right away. Make sure to tell your physician if you experience unexplained or irregular vaginal bleeding while taking this medication as well.

Norethindrone has a tendency to cause women depression. If you have a history of suffering depression in the past, consult your doctor promptly, especially if you think you might be having a relapse while undergoing norethindrone treatment. On that note, you will probably need to halt therapy. The long-term effects of this drug on the function of certain organs such as the uterus, liver, adrenal glands, ovaries, and pituitary glands are currently unknown.

Be warned that norethindrone can also affect blood sugar and cholesterol levels, so if you suffer from high cholesterol or diabetes, your doctor will want to monitor your blood sugar and cholesterol levels while you're under norethindrone therapy. This medication may also mask the onset of menopause. All the same, older women susceptible to menopause are still qualified to take norethindrone . Finally, if you are being tested for cancer, inform your doctor or lab technician that you are taking the medicine.

Norethindrone increases your risk for blood clots, which can lead to stroke, vision problems, breathing problems, and phlebitis. If you experience any of the following symptoms, then you may be suffering from the onset of a clot-related disorder: weakness or numbness in an arm or leg, migraine, loss of vision or double vision, coughing or shortness of breath, warmth and redness in a leg vein, or pain with swelling. You must stop taking this drug and consult your doctor promptly if any of the above side effects happen to you.

Other possible side effects from norethindrone usage include yellowing of the skin or eyes, weight increase or decrease, swelling, stopping of menstrual flow, skin discoloration, rash with or without itchy spots, nausea, mood swings, menstrual spotting, insomnia, inflammation of the optic nerve, hives, headache, change in menstrual flow, cervical changes or secretions, depression, bulging eyes, breast enlargement or tenderness, breakthrough menstrual bleeding, allergic reaction, and acne.

Norethindrone has the following structural formula:

Chemical structure of norethindrone

• Molecular formula of norethindrone is C20H26O2
• Chemical IUPAC Name is (8R,9S,10R,13S,14S,17S)-17-ethynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16- dodecahydrocyclopenta[a]phenanthren-3-one
• Molecular weight is 298.419 g/mol
Norethindrone available : 5mg tablets

Brand name(s): Anhydrohydroxynorprogesterone, Anovulatorio, Anovule, Aygestin, Binovum, Brevicon, Brevinor, Camila, Ciclovulan, Conceplan, Conludaf, Conludag, Demulen, Errin, Estrinor, Ethinylnortestosterone, Ethynylmortestosterone, Ethynylnortestosterone, Gencept, Genora, Gestest, Jenest, Levlen, Loestrin, Menzol, Microneth, Micronett, Micronor, Micronovum, Milli, Mini-Pe, Mini-Pill, Minovlar, Modicon, Necon, Nelova, Neocon, Nodiol, Noraethisteronum, Noralutin, Norcept, Norcept-E, Norcolut, Nordette, Noresthisterone, Norethadrone, Norethin, Norethindrone Acetate, Norethindrone Norethisterone, Norethisteron, Norethisterone, Norethisterone, Norethisteronum, Norethyndron, Norethynodron, Noretisterona, Noretisterone, Norfor, Norgestin, Noriday, Norimin, Norinyl, Norlestrin, Norlutate, Norluten, Norlutin, Norluton, Normapause, Norpregneninlone, Norpregneninolone, Norpregneninotone, Orlest, Ortho-Novum, Ovcon, Ovral, Ovrette, Ovysmen, Palonyl, Perovex, Primolut N, Proluteasi, Synphase, Tri-Levlen, Tri-Norinyl, Triella, Trinovum, Trinovum 21, Utovlan, Utovlar

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