People now have an answer to depression
. The TCA drug provides a great advantage in terms of mood and overall sense of well-being. Individuals should also learn the proper way of taking the drug to reduce the risks and fully enjoy the benefits.
Nortrilen is an antidepressant drug belonging to the tricyclic class or TCA group. Its generic name is nortriptyline
although it also has other brand names like Aventyl and Pamelor
. Nortrilen generally works to elevate the mood of patients suffering from depression. It is also useful as a sedative which aids symptoms
of depression like restlessness, anxiety
. The drug directly acts on brain neurotransmitters
to improve depressive states. It was also discovered to be effective in treating neuralgic pain and chronic pain.
Nortrilen can cause many side effects if taken improperly. Included are hypotension, hypertension
, arrhythmia, heart
block, cerebrovascular accident or stroke, tachycardia, palpitation, restlessness, hallucinations
, delusions, restlessness, anxiety, irritability, insomnia, panic, nightmares, hypomania, numbness, tingling sensation, ataxia, tremors
, extrapyramidal symptoms, dry mouth
, blurred vision, skin rash, abdominal cramps, jaundice, liver
, drowsiness, body weakness, fatigue, headache
and parotid swelling
Overdose of tricyclic depressants can be characterized by dizziness, blurred vision, restlessness, vomiting
, hypothermia, hyperthermia, seizures, respiratory depression, fever
, cardiac arrhythmias, hyperactive reflexes, agitation, dizziness, coma and renal failure. The patient’s airway should be the first priority during management.
Nortrilen is contraindicated in individuals taking MAO inhibitor drugs. Combination of MAO inhibitors and TCAs can cause hyperpyretic crisis, severe convulsions and fatalities. Nortrilen is also shown to have cross sensitivity to other dibenzazepines. Patients in the acute recovery period after myocardial infarction
should not take the drug. Pregnant women and breastfeeding mothers are also not allowed. Individuals should first consult their doctor regarding the proper dose, interactions and safety of use.
Nortrilen just like other tricyclic antidepressants acts on the neurotransmitters in the brain responsible for good mood like serotonin and norepinephrine
. Depressed patients usually have abnormal or low levels of these chemicals responsible for nerve
cell communication. Other receptors that usually bind these are inhibited as well so that more mood-elevating neurotransmitters will end up in the synaptic cleft. Once these accumulate, individuals will experience heightened sense of well-being.
25 depressed patients were given 25mg of Nortrilen three times a day for 6 weeks. After 3 weeks, all patients showed improved mood by as much as 25%. At the end of the clinical trial, all patients improved mood by as much as 40%. 11 of these were reported to be fully recovered from depression. 13 patients exhibited minor side effects like hallucinations, restlessness and drowsiness.
Nortrilen comes in 25 mg or 10 mg tablets. It is available in pharmacies and online. Make sure that the online store you’re buying from is verified and has an existing address and telephone number. Check the date of expiry as well as the manufacturer when checking labels to ensure quality, authenticity and safety.
Nortrilen should not be taken as a sleeping medication. However, patients may take the dose right before bedtime to make use of its sedative effects. Those taking MAO inhibitors should discontinue 2 weeks before starting Nortrilen treatment.
Nortrilen has the following structural formula:
• Molecular formula of nortrilen is C19H21N
• Chemical IUPAC Name is 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
• Molecular weight is 263.377 g/mol
• Nortrilen available : 10mg tablets, 25mg tablets