Nystatin review

As a polyene antifungal drug that many types of yeast and molds like Candida spp are sensitive to, nystatin has been known to exude toxicity whenever it's administered intravenously. However, uninjured or intact mucous membranes or skin shouldn't be able to absorb it. As such, it's considered a safe medication for treatment of gastrointestinal or oral fungal infections. It also has quite a lot of trade names associated to it because of its efficacy and widespread availability.

Sufferers of Candida infections that are esophageal, mucosal, vaginal, and cutaneous in nature are usually responsive to nystatin therapy. Cryptococcus is also vulnerable against this particular drug. Nystatin is only licensed in the United Kingdom to treat neonatal oral thrush for babies over the age of one month; that's because miconazole has been prescribed for younger babies suffering from that particular disorder.

The oral form of nystatin has other uses as well. For instance, it's can also be employed as prophylaxis in people who are most likely to develop fungal infections—that is, cancer patients receiving chemotherapy and AIDS patients with a reduced CD4+ count. Then there's nystatin's cream form that is best used for treatment of fungal skin infections like ringworm, athlete's foot, and jock itch. It's mechanism of action involves weakening the cell membranes of the fungus and making them leak out.

The oral from should be administered as follows unless otherwise instructed by your designated medical professional: Add the prescribed amount—typically one-eighth of a teaspoon—of dry powder into four ounces of water and stir well. From there, divide the mixture into smaller portions for immediate treatment (don't store any of them for later use). Afterwards, apply the mixture directly into the infected mouth and keep it in there for as long as you possibly can by swirling it inside your mouth. Gargle as well before swallowing if instructed by your physician.

As for the topical cream version of this medication, do the following: Clean the infected area with soap and water first and dry carefully. Apply just enough medicine on the affected part of your skin to cover it completely, and rub it as gently as you can. The medicine works best if used at a scheduled time daily. Remember to keep using nystatin cream even if the infection has already cleared up in a few days, and avoid using two doses at once.

Contact your healthcare professional or pharmacist if you experience any of the following common side effects for nystatin oral drugs: vomiting, diarrhea, upset stomach, nausea, and oral irritation.

Consult your pharmacist or doctor if any of these most frequent symptoms occur, persist, or worsen when using nystatin topical medications: streaking of the skin, skin wasting, secondary infection, loss of skin color, itching, irritation, inflammation of hair follicles, inflamed skin around the mouth, excessive hair growth, dryness, burning, cracking, and stinging of skin, and acne.

Seek immediate medical help if any of the following grave side effects happen when taking nystatin oral medication or cream: severe allergic reactions such as swelling of the tongue, lips, face, or mouth, tightness in the chest, difficulty in breathing, itching, hives, and rash.

Before taking either form of nystatin, make sure to inform your doctor or pharmacist about your medical history, especially if you've ever had any allergies to this drug, to any other drug, and to other substances. You should also disclose to him all nonprescription and prescription drugs you've recently used or are already using.

This medicine should only be administered when absolutely needed during pregnancy; discuss the pros and cons of doing so with your healthcare specialist. It's presently not known whether or not this drug passes through breast milk, so talk to your doctor first before attempting to breastfeed.

Finally, don't stop or start taking nystatin or any other medication on your own volition; you must seek medical or pharmaceutical approval first. Continue treatment until the full prescribed amount is finished even if the symptoms of your infection have disappeared long ago. Stopping prematurely can lead to infection relapse.

Nystatin has the following structural formula:

Chemical structure of nystatin

• Molecular formula of nystatin is C47H75NO17
• Chemical IUPAC Name is 20-(4-amino-3,5-dihydroxy-6-methyl- oxan-2-yl)oxy-4,22,24,28,29, 32,34,36- octahydroxy-2,3,5-trimethyl- 26,38-dioxo-1-oxacyclooctatriaconta-6,8,12, 14,16,18-hexaene-23-carboxylicacid
• Molecular weight is 926.09 g/mol

Brand name(s): Barstatin, Candex, Flagystatin, Korostatin, Mycostatin, Mykacet, Mykinac, Mytrex F, Nadostine, Nilstat, Nyaderm, Nysert, Nystaform, Nystex, Nystop

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