Ocu-Tropine review

Ocu-Tropine is a tropane alkaloid attained from Atropa belladonna (deadly nightshade), Datura stramonium (jimsonweed), Mandragora officinarum (mandrake), and other plants of the family Solanaceae. This multi-purpose medicament is a secondary metabolite of the above plants and provides a variety of effects and uses. Classified as an anticholinergic medicament, it serves as an aggressive antagonist for the muscarinic acetylcholine receptor. Also known as Atropen, this medicament gets its name from Greek Mythology and is named after Atropos, one of the three Fates.

On The World Health Organization's Essential Drugs List (a list of minimum medical requirements for a basic healthcare system), Ocu-Tropine is regarded a core medicine to any healthcare system.

Adult dosages vary from half a milligram to one milligram or five to ten milliliters of the 0.1 milligram/milliliter solution for antisialagogue and other antivagal effects, add two to three milligrams or twenty to thirty milliliters of the 0.1 milligram/milliliter solution as an antidote for organophosporous muscarinic poisoning.

When no IV is available, patients should use the endotracheal administration of Ocu-Tropine. One to two milligrams diluted to a total of no more than ten milliliters of normal saline or sterile water is the preferred adult dosage of Ocu-Tropine for endotracheal administration. Dosage intervals of one or two hours are suggested for cases that are not serious or critical.

Special consideration must be given to all patients over forty years of age when administering Ocu-Tropine Sulfate Injection (USP). Acute glaucoma may occur during Ocu-Tropine treatment in at risk patients. Patients with prostatic hypertrophy may develop complete urinary retention, convert partial organic pyloric stenosis into complete obstruction, or cause inspissation of bronchial secretions and form dangerous viscid plugs in patients with chronic lung illness. Due to these potentially dangerous conditions, you must make certain that your healthcare professional is aware of your complete medical history before starting treatment with Ocu-Tropine.

Since regular use of Ocu-Tropine is crucial in patients suffering from coronary artery illness, the total dosage needs to stay at or below two to three (maximum 0.03 to 0.04 milligrams/kilograms) to prevent the harmful side effects of Ocu-Tropine-caused tachycardia on myocardial oxygen demand.

Patients with bradyasystolic cardiac arrest should be administered a single milligram dosage of Ocu-Tropine intravenously and repeated every three to five minutes until symptoms subside. Three milligrams (0.04 milligrams/kilograms) administered intravenously is a sufficient vagolytic dosage in most patients. Note that the administration of less than 0.05 milligrams can produce a paradoxical bradycardia because of the peripheral or central parasympathomimatic effects of low dosage Ocu-Tropine in some adults.

When being used as an antidote, Ocu-Tropine's two to three milligram dosage should be repeated no less than every twenty to thirty minutes until symptoms are significantly reduced or until signs of Ocu-Tropine poisoning occur. Typically, the initial dosage of this medicament is usually around 0.01 to 0.03 milligrams/kilograms of body weight. Dosing information for children hasn't been well researched. This medicament should not be used on a child without consulting with a healthcare professional first.

Side effects include tachycardia, photophobia, blurred vision, and dryness of mouth. These symptoms commonly occur with chronic therapeutic dosages. For patients living in a hot climate, Anhidrosis (heat intolerance) and impaired temperature regulation may occur. Urination difficulties and costiveness may be experienced by elderly patients. Occasional hypersensitivity, rashes, and exfoliation have also been reported. If you experience any of these symptoms, consult your healthcare professional.

Side effects due to Ocu-Tropine poisoning include ataxia, fatigue, tremor, restlessness, dizziness, thirst, hot and dry skin, difficulty swallowing, dilated pupils, and palpitation. In some cases, it may lead to coma, delirium, hallucinations, restlessness and excitement, and marked palpitation. Severe intoxication while taking Ocu-Tropine can lead to circulatory collapse and depression. Due to this, patients are advised to avoid alcohol consumption altogether while taking this medicament. Seek immediately medical attention if you experience any of these symptoms.

Ocu-tropine has the following structural formula:

Chemical structure of ocu-tropine

• Molecular formula of ocu-tropine is C17H23NO3
• Chemical IUPAC Name is (8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenyl-propanoate
• Molecular weight is 289.369 g/mol
Ocu-tropine available : 5ml 1% bottles

Generic name: Atropine

Brand name(s): Atnaa, Atropair, Atropen, Atropin, Atropina, Atropinol, Atropisol, Atrosulf, Equipin, Eyesules, Hyoscyamine, I-Tropine, Isopto atropine, Minims atropine, Tropine tropate, Troyl tropate

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