is a xylometazoline nasal
spray manufactured by Novartis. It is a nasal decongestant that works by constricting blood vessels
in the nasal passages. This causes less water to seep through the blood
vessels and thus reduces discharge. Otrivin is used for the treatment of nasal congestion
caused by allergies
, hay fever
, cold, sinusitis
and ear infections
. It also comes in 0.1% and 0.05% solution variants, the later intended for younger users.
Otrivin may be administered by nasal sprays, measured dose pumps, or nasal drops. The recommended dosage for patients 12 years and older are one to two sprays (for nasal sprays), or two to three drops (for nasal drops), or one spray (for measured dose pumps) every eight to ten hours with Otrivin solution of 0.1%. For younger patients, 0.05% solution is prescribed, while doctors will have to make their own prescription for patients younger than 2 years old.
Do not double your dose of Otrivin if you miss taking a dose. However, do take Otrivin as soon as you remember to after missing a dose, unless the next dose is almost due.
Follow the doctor’s prescribed dosage and do not take the Otrivin for more than 3 days as prolonged use may aggravate congestion. Consult a doctor if the situation does not improve after 3 days.
Do not use Otrivin without consulting your doctor if you are also taking the following medication: blood pressure medication, certain antidepressants (such as amitriptyline
and MAO inhibitors), allergy
and cold medication and other decongestants. These drugs may interact with Otrivin to increase unwanted side effects.
Also, if you have high blood pressure
disease, type-2 diabetes
, an enlarged prostate
, thyroid or kidney
disease – Otrivin may aggravate your condition. Please inform you doctor if you have any other medical conditions.
For pregnant or lactating mothers, as with any drug, consult with your doctor before using Otrivin.
Overuse of Otrivin may worsen the congestion rather than relieve it, resulting in a condition of increasing recurrence of nasal congestion called rhinitis
medicamentosa or RM. This usually occurs after three to five days of continuous use. With the repeated use of xylometazoline sprays (as well as other topical nasal decongestants) to relieve congestion, the nose
develops a form of “resistance” to the drug and will require greater and more frequent doses to relieve the congestion once it recurs. When this happens it may be difficult to wean off Otrivin, as breathing can become very difficult without the use of medication. However, gradual withdrawal from the medication is necessary to overcome RM.
As your body gets used to Otrivin after first taking it, you may experience dryness or irritation of the nasal passages, sneezing
. This should eventually go away, but if these effects persist, consult your doctor.
You should also consult your doctors if you feel rapid or strong heartbeat, dizziness
and shaking, or trouble sleeping. However, if you feel your face or throat swelling
, or feel a lot of difficulty in breathing, seek medical assistance immediately.
Otrivin has the following structural formula:
• Molecular formula of otrivin is C16H24N2
• Chemical IUPAC Name is 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole
• Molecular weight is 244.37516 g/mol