Oxamide review

Oxamide is used to treat various types of cancer including testicular and sarcomas. It belongs to a group of cancer-fighting medications that inhibit the growth of cancer cells in the body.


Oxamide is available under the brand names Act-D and Actinomycin D and is commonly prescribed to children, but adults may also benefit from this medication. Oxamide is for the treatment of cancers of the soft tissue and bones particularly tendons and muscles, tumors in the womb, and cancer of the testicles.


Oxamide is injected in a vein for about 15 minutes. Patients are often given a medicine prior to Oxamide to stop any vomiting or nausea once the medication is administered.

The dosage of Oxamide depends on the patient's size, blood count, condition and the cancer being treated. Blood counts are typically taken before treatment of Oxamide K. If the lab tests indicate unsafe conditions, the treatment will be delayed.

It is typical for patients to take Oxamide with other chemotherapy dugs.


Oxamide can decrease the amount of white blood cells in the body for weeks, which can increase the patient's risk of infection. Patients should immediately inform their healthcare master if they experience symptoms of an infection including high fever, pain when urinating, chills, or coughs.

Oxamide can lower the platelet count of the patient for weeks after treatment, increasing the patient's risk of bleeding. Patients should notify their healthcare master if they experience unexplained bleeding including epistaxiss, tarry stools, or bleeding gums.

There is a risk that Oxamide will decrease the number of red blood cells in the body. Anemia, a decreased red blood cell count, often results in difficulty in breathing, and exhaustion. Your healthcare master may prescribe additional medicines to prevent this condition or you may need to have a blood transfusion.

Patients should not have any vaccinations while taking this medication without the prior consent of their healthcare master. Oxamide can affect a patient's immune system and alter the effectiveness of vaccinations and can lead to severe infections.


Oxamide can result in baldness. However, this is a temporary side effect and the hair typically grows back after the treatment.

Patients should talk with their healthcare master about their complete medical history, especially if they have had liver, kidney, heart illnesss, diabetes, heart failure, gout, kidney stones, and infections. These conditions may require a change in the dosage of Oxamide.

Patients treated with radiation are typically given decreased dosages of Oxamide.


This medication can affect the fertility of patients and cause birth defects, especially if the mother took Oxamide during pregnancy or conception. Patients taking Oxamide should use birth control to lessen risks of conception.

Oxamide has the following structural formula:

Chemical structure of oxamide

 Molecular formula of oxamide is C62H86N12O16
 Chemical IUPAC Name is 8-amino-N-(2-amino-4,6-dimethyl-3-oxo-phenoxazin-1-yl)carbonyl-N'-[8-amino-4,6-dimethyl-7-oxo-9-[[3,6,10-trimethyl-7,14-bis(1-methylethyl)-2,5,8,12,15-pentaoxo-9-oxa-3,6,13,16-tetrazabicyclo[14.3.0]nonadec-11-yl]carbamoyl]phenoxazin-1-yl]carbonyl-4,6-dimethyl-7-oxo-N,N'-bis[3,6,10-trimethyl-7,14-bis(1-methylethyl)-2,5,8,12,15-pentaoxo-9-oxa-3,6,13,16-tetrazabicyclo[14.3.0]nonadec-11-yl]-1,9-bis[[3,6,10-trimethyl-7,14-bis(1-methylethyl)-2,5,8,12,15-pentaoxo-9-oxa-3,6,13,16-tetrazabicyclo[14.3.0]nonadec-11-yl]carbamoyl]phenoxazine-1,9-dicarboxamide
 Molecular weight is 1255.42 g/mol
 Oxamide available : 0,5mg injection

Generic name: Dactinomycin

Brand name(s): Cosmegen, Dactinomicina, Dactinomycine, Dactinomycinum, Lyovac Cosmegen, Meractinomycin, Oncostatin K

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