is one of the earliest tetracycline
antibiotics ever produced. It was developed under the supervision of famed biochemist by the name Robert Woodward, who has both Scottish and American blood
. He was the one who worked out Oxytetracycline’s chemical structure at the Pfizer laboratory in 1953. This discovery and development did not just pave the way for Oxytetracycline or Terramycin to penetrate the market. It also played an important role in the discovery of Doxycycline
, which is one of today’s most widely used antibiotics.
Oxytetracycline is mostly used to treat infections that are both common and rare. It works by interfering with the bacteria’s protein production, which is essential for their growth. Oxytetracycline stops the spread of the bacteria infection while the immune system kills the rest of them.
Oxytetracycline is a broad-spectrum tetracycline antibiotic. It can be used against a wide number of bacteria. Then again, some bacteria developed strong resistance to this antibiotic, making it ineffective in some forms of infection.
Oxytetracycline is widely used against some chest, eye, and genital infections. It has also been used for the treatment of acne
. For doctors to be sure that the bacteria causing your ailment are vulnerable to Oxytetracycline, he may require blood or urine tests.
There are a number of precautions that patients must take prior and during Oxytetracycline treatment. This is to ensure the patient’s safety and the efficiency of the drug as well.
Oxytetracycline is contraindicated to patients with allergy
to the drug and to its components. It must also be used carefully by patients with liver
ailments, blood disorders
, long-term skin inflammations, and muscle weakness. Oxytetracycline must not be used to young children (12 years and below), pregnant and lactating women, and those patients with kidney
Oxytetracycline must not be taken with food, milk, and iron preparations. It is advised that your dosage schedule is at least one hour before meal time or two hours after. This will help boost Oxytetracycline’s effects. The absorption of Oxytetracycline is much more efficient without the above-mentioned elements.
The usual dosage of Oxytetracycline is 250mg or 500mg tablet, capsule, or liquid suspension every six hours. In some cases, Oxytetracycline is used as an injection, cream, or eye drops. It is important that patients follow their doctor’s prescription because a specific amount of Oxytetracycline needs to be maintained in the blood to be effective. A decision to stop or continue taking the medicine must be directed by the doctor and not by anyone else. Oxytetracycline must be taken continuously even after the patient feels an improvement in their symptoms. Stopping the medication abruptly may increase the risk for re-infection and for the bacteria to become resistant to the antibiotic.
Oxytetracycline may cause several side effects including nausea
, appetite loss, and oversensitivity to sunlight. Such adverse reactions usually go away as soon as the body becomes familiar with the drug. If your symptoms persist or worsen, call your doctor immediately.
To lessen your skin’s vulnerability during Oxytetracycline treatment, you must avoid too much sunlight exposure. You must also take caution in using UV light through sunlamps or sun beds.
Oxytetracycline has the following structural formula:
• Molecular formula of oxytetracycline is C22H24N2O9
• Chemical IUPAC Name is (2Z,4S,4aR,5S,5aR,6S,12aS)-2-(amino-hydroxymethylidene)-4-dimethylamino- 5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione
• Molecular weight is 460.4340 g/mol
• Oxytetracycline available : 250mg tablets