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Panretin

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Panretin

Panretin review





Panretin, also known as Toctino, is an antineoplastic agent developed by Ligand Pharmaceurinary tract infectioncals. It is a first-generation retinoid that Ligand gained Food and Drug Administration approval of in February 1999.

The gel form, called Panretin, is used to treat people with skin lesions and Acquired immune deficiency syndrome-related Kaposi's sarcoma, while the capsule, called Toctino, is used to treat patients with chronic hand eczema. Chemically related to Vitamin A, Panretin is a yellowish powder with a molecular formula of C20H28O2 and a molecular weight of 300.44.

Panretin should be applied two times a day to cutaneous KS lesions during the initial stages of treatment. You may apply the gel liberally in order to cover the lesion with a generous coating, and then allow it to dry for three to five minutes before covering it with clothing. Avoid applying the gel on or near mucosal surfaces (nose, mouth, and eyes) of your body.

As for Toctino, it must be taken after every meal and swallowed whole. Dosage ranges from 10 milligrams to 30 milligrams once every day for twelve weeks (three months) to twenty-four weeks (six months) depending on the severity of the eczema. Consult your doctor immediately if your body can't handle the recommended daily dose so that they can alter your prescription.

The typical side effects of Panretin are itching, a burning sensation, and mild redness of the skin. You should notify your doctor immediately for these less common side effects: cracking or oozing skin, blistering, stinging or tingling skin, peeling, skin edema, rash, and severe redness. It's rare for patients under Panretin treatment to get sunburn, but if you do get it, you must consult your physician as soon as possible.

As for the common side effects of the Toctino capsule, you might experience eye problems, eye inflammation or conjunctivitis, thyroid problems, decreased clotting or other blood cell disorders, flushing, muscle and arthralgia, liver problems, dry skin, inflamed skin, and baldness. Ask a pharmacist for eye drops if you need to continue Toctino treatment despite its eye-related side effects. It's recommended for you to wear glasses instead of contacts while undergoing Toctino therapy.

Before taking Panretin, talk with your healthcare specialist about your medical history, including occurrences of tumors like lymphoma, skin conditions, and allergies. This medicament has been known to induce sunburn, so you should wear sunscreen and protective clothing while undergoing Panretin treatment and keep the treated areas of your skin away from sunlamps. Consult your pharmacist for any further questions or concerns.

Avoid taking Toctino if you are currently taking tetracycline (a type of antibiotic); if you are allergic to Panretin, other ingredients of Toctino, or any other retinoids such as isotretinoin; if you have very high levels of Vitamin A in your body; if you have untreated thyroid illness; if you have high blood fats such as raised triglycerides or high cholesterol; if you have severe kidney illness; and if you have liver illness.

Expecting mothers should avoid using either version of this medicament (Panretin or Toctino) during pregnancy because it may harm your unborn baby once it's absorbed into your bloodstream. It is not known whether this medicament passes into breast milk, so it's not advised for breastfeeding mothers to use this medicament. Notify your doctor before using this medicament while pregnant or breastfeeding a newborn.

Panretin has the following structural formula:

Chemical structure of panretin


• Molecular formula of panretin is C20H28O2
• Chemical IUPAC Name is 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,6,8-tetraenoic acid
• Molecular weight is 300.435 g/mol

Generic name: Alitretinoin

Brand name(s): Avita, Beta-retinoic acid, Panretyn, Panrexin, Renova, Retin-A, Retinoate, Retinoic acid, Trans-Retinoic acid, Tretinoin, Vesanoid, Vitamin A acid

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