Panrexin review

Panrexin, also known as Panretin or Toctino, is an antineoplastic agent developed by Ligand Pharmaceurinary tract infectioncals. It is a first-generation retinoid that Ligand gained Food and Drug Administration approval of in February 1999.

As "Panretin", it is a gel used to treat people with skin lesions and acquired immunodeficiency syndrome-related Kaposi's sarcoma, while as "Toctino", it is a capsule used to treat patients with chronic hand eczema. Panrexin is chemically related to Vitamin A and is a yellowish powder with a molecular formula of C20H28O2 and a molecular weight of 300.44.

Panretin, the gel version, should be applied two times a day to cutaneous KS lesions during the initial stages of treatment. Apply the gel liberally to cover the lesion with a generous coating, and then allow it to dry for three to five minutes before covering it with clothing. Avoid applying the gel on or near mucosal surfaces (nose, mouth, and eyes) of your body.

The Toctino capsule should be taken after every meal and swallowed whole. The recommended dosage is 10 mg to 30 mg daily for twelve to twenty-four weeks depending on the severity of the eczema. Consult your doctor immediately if notice any of the side effects listed below.

The typical side effects of Panretin are itching, a burning sensation, and mild redness of the skin. You should notify your doctor if you experience and of these less common side effects: cracking or oozing skin, blistering, stinging or tingling skin, peeling, skin edema, rash, and severe redness. It's rare for patients under Panretin treatment to get sunburn, but if you do, consult your physician as soon as possible.

As for Toctino, the common known side effects include eye problems, eye inflammation or madras eye, thyroid problems, decreased clotting or other blood cell disorders, flushing, muscle and arthralgia, liver problems, dry skin, inflamed skin, and hair loss. Ask a pharmacist for eye drops if you need to continue Toctino treatment despite its eye-related side effects. It's recommended that you wear glasses instead of contacts while taking Toctino.

Before taking either medicament, you should discuss your medical history with your doctor. This should include a discussion of occurrences of tumors like lymphoma, skin conditions, and allergies. Panretin has been known to induce sunburn, so you should wear sunscreen and protective clothing while undergoing Panretin treatment. You should also keep the treated areas of your skin away from sunlamps. Consult your pharmacist or doctor with any additional queries and concerns.

Avoid taking Toctino if you are currently taking tetracycline (a type of antibiotic); if you are allergic to Panrexin, other ingredients of Toctino, or any other retinoids such as isotretinoin; if you have very high levels of Vitamin A in your body; if you have untreated thyroid disease; if you have high blood fats such as raised triglycerides or high cholesterol; if you have severe kidney disease; and if you have liver disease.

Expecting mothers should avoid using either version of this medicament (Panretin or Toctino) during pregnancy because it may harm your unborn baby once it's absorbed into your bloodstream. It is not known whether this medicament passes into breast milk, so it's not advised for breastfeeding mothers to use this medicament. Notify your doctor before using this medicament while pregnant or breastfeeding a newborn.

Panrexin has the following structural formula:

Chemical structure of panrexin

• Molecular formula of panrexin is C20H28O2
• Chemical IUPAC Name is 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,6,8-tetraenoic acid
• Molecular weight is 300.435 g/mol

Generic name: Alitretinoin

Brand name(s): Avita, Beta-retinoic acid, Panretin, Panretyn, Renova, Retin-A, Retinoate, Retinoic acid, Trans-Retinoic acid, Tretinoin, Vesanoid, Vitamin A acid

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