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Perindopril

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Perindopril

Perindopril review





Perindopril is an Angiotensin-Converting Enzyme or ACE inhibitor that is primarily used for the treatment of hypertension and congestive heart disease. It is marketed by Servier Laboratories under the trade name Coversyl. Perindopril is also available in generic formulations.

Perindopril blocks the activity of ACE, which interferes with the normal blood flow. It relaxes the blood vessels, normalizes the blood flow, and lowers the blood pressure. If blood pressure is in a normal level, the heart does not need to work as hard in pumping the blood around, which lowers the risk for heart attack and heart failure.

As with any other drug used for medication treatment, special precautionary measures must be taken before and during treatment. This is to ensure the patient’s safety with the drug. It will also help a lot in determining whether one is fit to receive the full benefits of the drug or not.

Perindopril is contraindicated to patients who might develop an allergic reaction against it. This is more likely to occur if you are hypersensitive to drugs. Perindopril is also not advisable for use among pregnant women. The drug has been found to cause fetal harm, which may result to birth defects and even prenatal death. Perindopril also passes through the breast milk. Nursing mothers must consult the doctor about taking the medicine to avoid causing harm to their newborns.

Perindopril is also contraindicated to patients with history of Angioedema. This condition characterized by swelling of the face, lips, and tongue, is mostly prohibited to be used with the drug.

Perindopril must be used with caution to patients who are 65 and older, have liver and kidney disorders, use diuretic drugs, have heart disease, or are diabetic. Treatment with this drug must be monitored closely to ensure that both the blood pressure and the kidney functions are normal.

Perindopril is an oral drug. It comes in tablet form that is usually taken one to two times daily. The standard prescription is started on a low dosage, which is increased over time. It must be noted that Perindopril is not a cure for hypertension. It is only meant to control the symptoms.

Like other drugs, Perindopril may come with unwanted effects along with the beneficial effects. The symptoms of side effects that you may experience are usually mild and temporary. As soon as you body becomes familiar with the drug, any episode of cough, headache, dizziness, weakness, diarrhea, and stomach pain should go away. If they persist, worsen, or came with less common side effects such as swelling of the face, lips, tongue, and other body parts, hoarseness, breathing difficulty, irregular heartbeat, and fever, call your doctor immediately.

The adverse effects of any drug should not overpower its efficiency in treating your condition. If you feel that your symptoms are becoming difficult to handle, you must talk to your doctor for possible dosage adjustment. In some cases a totally different drug with similar effects is prescribed. In any case, your doctor would certainly know what is the best thing to do. He should be your only source of advice.

Perindopril has the following structural formula:

Chemical structure of perindopril


• Molecular formula of perindopril is C19H32N2O5
• Chemical IUPAC Name is 1-[2-(1-ethoxycarbonylbutylamino)propanoyl]-2,3,3a,4,5,6,7,7 a-octahydroindole-2-carboxylicacid
• Molecular weight is 368.468 g/mol
Perindopril available : 2mg tablets, 4mg tablets, 8mg tablets

Brand name(s): Aceon, Coversyl, Coversyl Plus, Preterax

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