Persantine is a brand name for the medication dipyridamole, which is prescribed to stop your platelets from sticking together so that they can’t attach to the surfaces of artificial heart valves. This helps prevent blood clots from forming around the artificial valve and getting into the heart, brain, or lungs, where they can cause heart attacks, strokes, or pulmonary embolisms. It is also used to prevent blood clots from forming after heart valve replacement surgery. It is given to people who have had a heart attack in order to prevent death, and afterward it is given to prevent another heart attack. Persantine comes as a tablet which is usually taken four times a day, and is often used in conjunction with blood thinners such as warfarin. It can also be used to prevent strokes or blood clots on the brain, transient ischemic attacks, or obstruction of blood vessels by blood clots. It should be taken on an empty stomach unless this causes your stomach to be upset, and then it can be taken with food.
Persantine can cause several side effects. These are usually minimal and pass quickly. They can include a higher risk of uncontrolled bleeding, dizziness, stomach ache, headache, rash, diarrhea or vomiting, flushing, or itching. Other more severe side effects of Persantine can include unusual bleeding or bruising, arthritis, muscle aches, weakness, hair loss, low blood pressure, irregular heart beat, yellowing of the skin or eyes, confusion, severe headache, slurred speech, changes in your vision, weakness on one side of the body, or chest pain. If you experience any of these, you should contact your doctor. Some people may experience a severe allergic reaction to Persantine, though this is rare. Call your doctor if you experience a rash or hives, itching, swelling of the face, lips, tongue, or throat, severe dizziness, or difficulty breathing.
Studies in animals indicated no danger to a pregnant woman or her fetus; however, since animal studies are not always indicative of human reactions, you should be very careful in taking Persantine while you are pregnant. It is known, however, that Persantine is excreted in breast milk, so you should be very careful in taking Persantine if you are nursing. Persantine has not been tested for safety in children under the age of twelve, so pediatric use is not recommended.
Persantine should not be used by people with low blood pressure. It can also exacerbate the symptoms of liver disease or kidney disorders. People who have a history of heart problems or a recent heart attack should be very careful about taking Persantine and should avoid taking it with aspirin. Other interactions that could be dangerous include Alzheimer’s drugs such as Aricept, Cognex or Exelon, blood thinners such as Coumadin, heart medications such as adenosine, and other medications such as indomethasin, ticlopidine, or valporic acid. Because Persantine can make you dizzy, you should avoid driving or operating any heavy machinery, or any activity that requires mental alertness. You should also limit your intake of alcohol, which can make side effects worse.
Persantine has the following structural formula:
• Molecular formula of persantine is C24H40N8O4
• Chemical IUPAC Name is 2-[[3-[bis(2-hydroxyethyl)amino]-5,10-bis(1-piperidyl)-2,4,7,9-tetrazabicyclo [4.4.0]deca-2,4,7,9,11-pentaen-8-yl]-(2-hydroxyethyl)amino]ethanol
• Molecular weight is 504.626 g/mol
• Persantine available : 25mg tablets, 50mg tablets, 75mg tablets
Generic name: Dipyridamole
Brand name(s): Aggrenox, Agilease, Anginal, Apricor, Cardioflux, Cardoxil, Cardoxin, Chilcolan, Cleridium, Coribon, Coridil, Coronarine, Corosan, Coroxin, Curantyl, Dipiridamol, Dipyridamine, Dipyridamol, Dipyridan, Dipyudamine, Dypyridamol, Gulliostin, Justpertin, Kurantil, Natyl, Novo-Dipiradol, Peridamol, Permiltin, Persantin, Piroan, Prandiol, Protangix, Stenocardil, Stenocardiol, Stimolcardio
Review published on: 16 January 2008
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