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Phenytoin

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Phenytoin

Phenytoin review





Convulsions and seizures caused by epilepsy are difficult to manage, especially since they happen unexpectedly. Epileptic patients are often reduced to go through every day normally. The impact of an attack is just too much to take for anyone – from the victim down to mere onlookers.

The medical world has been working hard ever since to address this condition. Although the drugs developed were often not sufficient to completely cure epilepsy, they were enough to make the patients more comfortable even with the disease. Anticonvulsants are primarily there to control the frequency and severity of an attack, which is often enough to help epileptic patients live as normal as any other person.

One of the earliest and most successful results of clinical research intended for epilepsy is Phenytoin. Phenytoin is an anticonvulsant drug that was developed in early 1950s. It was given the go signal by the Food and Drug Administration to be used for epilepsy in 1953. At present, Phenytoin is available worldwide under different brand names from different pharmaceutical companies.

Phenytoin works by interfering with the brain activity that induces seizures. It is also used in other neuropathic disorders and in several cardiac arrhythmias. Phenytoin is a prescription medicine that should be used with utmost care.

Before you can take a Phenytoin prescription, you will have to talk to your doctor about certain variables that may affect its effectiveness in treating your condition. Your doctor needs to establish that the benefits of the drug are far greater than its possible adverse effects.

Phenytoin is contraindicated to patients with allergy to the drug, its other components, and with other drugs as well. Your doctor would also need to know about all your medications, prescription or nonprescription, to ensure that drug interaction is not likely to occur.

Phenytoin is caused with caution to patients with history of several conditions including hypotension, irregular heartbeat, diabetes, blood, kidney, liver, and heart disorders. It is also not advised to be used by pregnant and lactating women without proper medical advice.

Phenytoin is an oral medication that comes in capsule, tablet, and liquid forms. The standard dosing schedule is twice to thrice daily, depending on the patient’s age, health condition, and responses to the medicine. When using extended-release capsules, however, the dosing schedule is once a day, usually every night.

It is important that you follow your doctor’s instructions in taking Phenytoin carefully. This is to ensure that you are safe with the drug and that your risks of experiencing severe side effects are low. Side effects are common with any kind of medication treatment. In case of Phenytoin use, drowsiness, vomiting, loss of appetite, and insomnia among others are normal. You need prompt medical attention if your symptoms of side effects worsen or did not go away in a short while.

Do not stop or continue taking Phenytoin without your doctor’s knowledge. Every move in your dosage must be done solely by your doctor. Stopping abruptly on a Phenytoin treatment comes with withdrawal symptoms that are characterized by increased seizures. It is important that the drug is taken out of your system gradually. Your doctor might require a decreased dosage over a period of time to serve the purpose.

Phenytoin has the following structural formula:

Chemical structure of phenytoin


• Molecular formula of phenytoin is C15H12N2O2
• Chemical IUPAC Name is 5,5-diphenylimidazolidine-2,4-dione
• Molecular weight is 252.268 g/mol
Phenytoin available : 30mg capsules, 100mg capsules, 125mg/5ml suspension 237ml bottle

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