Pioglitazone review

Diabetes Mellitus 2 sufferers can now rely on Pioglitazone to normalize their glucose levels. They also have to know the proper dosage and contraindications to avoid adverse effects.

Pioglitazone is the generic name of the prescription drug which belongs to a class called thiazolidinediones. It also comes under the brand names Actos and Duetact mainly used to treat diabetes mellitus type 2 or non-insulin dependent diabetes mellitus (NIDDM). The drug may also be used in conjunction with metformin, insulin or sulfonylurea. Pioglitazone comes in the form of tablets and should be taken by mouth. It controls insulin but does not cure it. The medication also has other unlabled uses like treatment of non-alcoholic steatohepatitis or fatty liver.

Pioglitazone can cause a variety of side effects such as hypoglycemia, shakiness, dizziness, sweating, lightheadedness, nervousness, irritability, pale skin, hunger, jerky movements, sudden mood or behavioral change, headache, numbness or tingling sensation in the mouth. Other serious adverse effects include confusion, seizure, loss of consciousness and hyperglycemic symptoms such as weakness, blurred vision, extreme hunger, extreme thirst, jaundice, vision loss, vomiting and frequent urination.

Contraindications for Pioglitazone include hypersensitivity or allergic reactions to the drug and current consumption of drugs that may cause untoward interactions such as ketoconazole, midazolam, atorvastatin, hormonal contraceptives, rifampin, nifedipine and montelukast. Those with underlying conditions like diabetes mellitus 1, diabetic ketoacidosis, lactation, pregnancy and individuals below 19 years old are also prohibited from taking the drug. Those who think that they’re pregnant or who are trying to get pregnant should not take the drug as well. Patients who are about to undergo surgery including dental surgery should inform their doctor about consumption of medication.

The drug’s mechanism of action is to lower blood glucose by boosting target cell reaction to insulin without having to increase pancreatic insulin production. Pioglitazone is a thiazolidinedione antidiabetic highly dependent on insulin in order to have significant effects. It is also a highly selective agonist for PPARgamma or peroxisome proliferators-activated receptor-gamma in which receptors can affect gene production for lipid and glucose metabolism.

18 patients with NIDDM were included in a clinical trial wherein half of the group took 30 mg of Pioglitazone once a day. The rest were placed on a placebo for 4 months. At the end of the study, those who were on the drug showed significant improvement in blood sugar levels compared to the placebo group. Conclusions were then drawn which proved the efficacy of the drug to treat NIDDM.

As a prescription drug, Pioglitazone will only be released by pharmacies, online drugstores and clinics with doctor’s recommendations. When buying online, make sure that you check for authenticity by knowing the right and existing address and contact number of the source and manufacturing company.

Do not take more than 30 mg during monotherapy or more than 45 mg when used with other antidiabetic drugs. Pioglitazone should be stored in a tightly sealed container away from moisture, light and children’s reach. Constantly monitor your blood sugar and glycosolated hemoglobin to know how your body is responding to the drug.

Pioglitazone has the following structural formula:

Chemical structure of pioglitazone

• Molecular formula of pioglitazone is C19H20N2O3S
• Chemical IUPAC Name is 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione
• Molecular weight is 356.44 g/mol
Pioglitazone available : 15mg tablets, 30mg tablets

Brand name(s): Actos, Actost, Pioglitazona, Pioglitazonum

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