Prednisolone review

Prednisolone is a glucocortoid, which is an adrenocortical steroid that occurs both naturally and artificially and given as a syrup. It is given for several different illnesses and conditions:
• It is indicated to treat endocrine conditions including congenital adrenal hyperplasia, nonsuppurative thyroiditis, and the type of hypercalcemia associated with cancer.
• It is also given for the short-term treatment of rheumatic disorders such as psoriatic arthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, bursitis, tenosynovitis, gouty arthritis, osteoarthritis—especially following an injury, synovitis due to osteoarthritis, and epicondylistis.
• Prednisolone is also used to treat collagen disorders, such as lupus and rheumatic carditis.
• It is given for skin disorders such as pemphigus, bullous dermatitis herpetiformis, Stevens-Johnson syndrome, exfoliative dermatitis and seborrheic dermatitis, psoriasis, and mycosis fungoides.
• It also treats allergic states such as seasonal allergies, asthma, rash or hives, atopic dermatitis, serum sickness, and hypersensitive reactions to drugs.
• Other uses include problems with the eyes such as allergies that manifest as ulcers in the corneas, herpes zoster ophthalmicus, segment inflammation, posterior uveiris and choroiditis, allergic pink-eye, keratitis, sympathetic ophthalmia, optic neuritis, chorioretinitis, iritis and iridocyclitis.
• Prednisolone is given to treat respiratory conditions, as well, including symptomatic sarcoidosis, Loeffler’s syndrome, Berylliosis, pulmonary tuberculosis, and aspirator pneumonitis.
• It is a treatment for blood disorders such as idiopathic thrombocytopenic purpura, secondary thrombocytopenia, acquired anemia, erythroblastopenia, and congenital hypoplastic anemia.
• It is also indicated for leukemias and lymphomas in adults and acute leukemia in children.
• It can be given to treat ulcerative colitis and regional enteritis, as well as treating other serious conditions such as tuberculosis meningitis, trichinosis, and polymyositis.

Side effects of Prednisolone can be quite serious and can include sodium retention, fluid retention, congestive heart failure, high or low blood pressure, potassium loss, alkalosis, weakness of your muscles, loss of muscle mass, osteoporosis, compression fractures in the vertebrae, necrosis in the bones of the leg, fractures in the bones of the leg, peptic ulcers, pancreatitis, esophagitis, distention of the abdomen, reduced ability to heal, thin skin, red or brown spots on the skin, increased sweating, convulsions, increased intracranial pressure, dizziness, headache, irregular periods, suppression of growth in children, lower tolerance of carbohydrates, symptoms of diabetes, increased need for insulin for those who are already diabetic, cataracts, increased pressure inside the eyes, glaucoma, and negative nitrogen balance due to protein irregularities. Prednisolone should also not be used on anyone with a systemic fungal infection, and you should not receive any inoculations while you are taking it, as it can suppress your immune system.

No adequate studies have been done to demonstrate whether Prednisolone is safe to take during pregnancy or while breast feeding. If you are pregnant or planning to become pregnant, or if you plan to breast feed your baby, discuss with your doctor the possible benefits and risks of your particular illness and dosage of Prednisolone. In many cases, doctors advise against beginning a course of treatment whose effects on an unborn or newborn baby are unknown.

Prednisolone has the following structural formula:

Chemical structure of prednisolone

• Molecular formula of prednisolone is C22H29FO5
• Chemical IUPAC Name is 9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9, 10,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• Molecular weight is 392.461 g/mol
Prednisolone available : 0.5mg tablets, 1mg tablets

Generic name: Methylprednisolone

Brand name(s): Besonia, Cortalone, Delta-Cortef, Depo-Medrol, Dopomedrol, Esametone, Fernisolone-P, Firmacort, Lemod, Medesone, Medixon, Medrate, Medrol, Medrone, Mesopren, Metastab, Methyleneprednisolone, Methylprednisolon, Methylprednisolonum, Meti-Derm, Metilbetasone, Metilprednisolona, Metilprednisolone, Metrisone, Metrocort, Metysolon, Moderin, Nirypan, Noretona, Prelone, Promacortine, Reactenol, Sieropresol, Solomet, Solu-Medrol, Sterane, Suprametil, Urbason, Urbasone, Wyacort

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