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Pregabalin

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Pregabalin

Pregabalin review





Patients suffering from symptoms due to damaged nerves may now feel more comfortable and relieved with Pregabalin. The drug effectively treats pain by acting on the central nervous system.

Pregabalin is the generic name of the anticonvulsant drug mainly used to treat neuropathic pain in adjunct therapy for partial seizures. It also comes under the brand name Lyrica. Other indications for the drug include generalized anxiety disorder, fibromyalgia pain and spinal cord injury. Pregabalin then alleviates symptoms such as rash or shingles, pain from damaged nerves in the extremities and muscle stiffness and tiredness. As an anticonvulsant, the medication acts be reducing the number of pain signals sent out by damaged nerves to minimize pain responses. It comes in the form of capsules to be taken orally.

Pregabalin can cause side effects like any other drug. Examples are tiredness, headache, nausea, vomiting, constipation, gassiness, bloating, elevated mood, dizziness, speech problems, confusion, difficulty concentrating, lack of coordination, difficulty remembering things, weakness, increased appetite, weight gain, uncontrollable jerking of body parts, swelling of the extremities and back pain. Serious side effects include blurred vision, double vision and eyesight changes, hives, rash, itching, shortness of breath, wheezing, chest pain, muscle pain, fever, blisters and swelling of the lips, eyes, neck or head. Less common side effects include fast heartbeat, cough, chills, labored breathing and sore throat.

Contraindications for the drug include hypersensitivity reaction to the drug. Special precautions should be given to individuals taking ACE inhibitors like benazepril, captopril, quinapril and ramipril, antidepressants, antihistamines, anti-anxiety drugs like lorazepam, anti-diabetic drugs like pioglitazone and rosiglitazone, narcotic pain medications, sedatives and tranquilizers. Doctors should be fully informed about substance abuse and underlying conditions such as alcoholism, drug abuse, kidney or heart disease, bleeding disorders, throat or vision problems, pregnancy and lactation. Patients should also inform their doctors if they are planning to get pregnant or about to undergo surgery.

The mechanism of action of Pregabalin is to bind to the alpha2-delta site in central nervous system tissues. Although the true action is not known, it is believed to affect calcium channel function by reducing some neurotransmitter calcium dependent discharge. Pregabalin is derived from GABA but does not bind to GABAB, GABAA or other benzodiazepine receptors. The drug binds to the a28 subunit of the calcium channel which is voltage-dependent.

14 patients diagnosed with epilepsy were included in a trial wherein they were divided into two groups. The first group was given 75 mg of Pregabalin twice a day while the rest were given a placebo for a duration of 8 weeks. At the end of the study, researchers concluded that Pregabalin is truly an effective anticonvulsant drug as evidenced by reduced symptoms among the first group of patients compared to the placebo group.

Pregabalin is readily available in most pharmacies and online drugstores. When ordering online, make sure that you verify the source that it only sells authentic and certified products. Read the labels, manufacturing company, address and expiry date carefully for safer transactions via the internet.

The recommended dose of Pregabalin is usually 75 mg twice a day or 50 mg thrice a day for adults. If you miss a dose of the drug, take one as soon as you remember but do not double the dose. If it is almost time for your next dose, skip the missed one altogether and take the next one due. Keep the drug in a tightly sealed container away from heat and children’s reach.

Pregabalin has the following structural formula:

Chemical structure of pregabalin


• Molecular formula of pregabalin is C8H17NO2
• Chemical IUPAC Name is 3-(aminomethyl)-5-methyl-hexanoic acid
• Molecular weight is 159.226 g/mol
Pregabalin available : 25mg capsules, 50mg capsules, 75mg capsules, 100mg capsules, 150mg capsules, 200mg capsules, 225mg capsules, 300mg capsules

Brand name(s): Lyrica

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