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Prinzide

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Prinzide

Prinzide review





Prinzide is a blood pressure treatment medication produced by Merck and Co. It is composed of two kinds of drugs, lisinopril and hydrochlorothiazide. Lisinopril is an angiotensin converting enzyme (ACE) inhibitor that inhibits an enzyme that causes tightening of blood vessels, thus allow the blood pressure to fall with the widening of blood vessels. Hydrochlorothiazide is a diuretic that then acts on the kidneys to purge the excess water and salt in the body, further lowering the blood pressure. Prinzide comes in 10mg lisinopril-12.5mg hydrochlorothiazide, 20mg lisinopril -12.5mg hydrochlorothiazide, and 20mg lisinopril -25mg hydrochlorothiazide tablets.

The effective dosage for each component of Prinzide during combination treatment is 10-80mg of lisinopril and 6.25-50mg of hydrochlorothiazide. Prinzide can be safely taken either with or without food. However, try to take the medicine the same time everyday, if possible in the morning. A lower dose may be prescribed if you are already taking blood pressure control medication or have kidney problems. Effects of Prinzide may take 2-4 weeks to fully manifest. Continue the use of this medication even if you feel fine, as Prinzide does not really “cure” high blood pressure but only maintains it.

ACE inhibitors such as lisinopril have been known to cause fetal injury or even death when the pregnant mother is exposed the drug especially during the second and third trimester. Doctors should be informed immediately if you have any plans of being pregnant or if you are unsure if you are pregnant so that Prinzide use may be immediately discontinued.

Since Prinzide contains a diuretic, fluid and electrolyte balance is a concern due to the possible increase in potassium that you may experience. Also, the high concentration of uric acid caused by the drug may cause gout and affect kidney function, and may also aggravate existing kidney conditions. Diabetic patients may also find it harder to control their blood glucose level when taking hydrochlorothiazide.

Your blood pressure may also drastically drop when taking Prinzide, which can be aggravated by a low-salt diet, low intake of fluids, or by perspiration or vomiting. Some anesthetics may also cause this, so it is important to inform surgeons and dentists that you are taking this medication before surgery.

Those taking allergy-desensitizing treatments may also get a severe allergic reaction when exposed to ACE inhibitors during treatment.

Substances that may affect or increase Prinzide’s effects include nonsteroidal anti-inflammatory drugs, diuretics, potassium supplements, other blood pressure medications, alcohol, barbiturates and narcotic medication.

Prinzide’s side effects commonly include cough, dizziness, fatigue, diarrhea and headache. These should not be any reason to discontinue medication but if these effects worsen or if any allergic reaction to Prinzide are observed then you should consult your doctor.

However, if fainting or symptoms of low white blood cell count (sore throat, fever) or liver injury (such as fever, nausea, yellowing of skin, swelling of glands), then immediate medical attention is required as these are more serious effects which may lead to complications.

You should also look out for symptoms of excess or deficiency in potassium such as thirst, dryness of mouth and throat, irregular heartbeat, weakness and cramps in the legs, numbing or tingling sensations or mood swings.

Prinzide has the following structural formula:

Chemical structure of prinzide


• Molecular formula of prinzide is C7H8ClN3O4S2
• Chemical IUPAC Name is 9-chloro-5,5-dioxo-5^6-thia-2,4-diazabicyclo[4.4.0]deca-6,8,10-triene-8-sulfonamide
• Molecular weight is 297.741 g/mol
Prinzide available : 10mg lisinopril and 12.5mg hydrochlorothiazide tablets, 20mg lisinopril and 12.5mg hydrochlorothiazide tablets and 20mg lisinopril and 25mg hydrochlorothiazide tablets.

Generic name: Hydrochlorothiazide

Brand name(s): Acuretic, Aldactazide, Aldoril, Apresazide, Aquarills, Aquarius, Bremil, Caplaril, Capozide, Chlorosulthiadil, Chlorothiazide, Chlorzide, Cidrex, Dichlorosal, Dichlorotride, Dichlotiazid, Dichlotride, Diclotride, Dicyclotride, Dihydrochlorothiazid, Dihydrochlorothiazide, Dihydrochlorothiazidum, Dihydrochlorurit, Dihydrochlorurite, Dihydroxychlorothiazidum, Direma, Disalunil, Diu-Melusin, Diuril, Drenol, Dyazide, Esidrex, Esidrix, Esimil, Fluvin, Hidril, Hidrochlortiazid, Hidroronol, Hidrotiazida, Hydril, Hydrochlorothiazid, Hydrodiuretic, Hydrodiuril, Hydropres, Hydrosaluric, Hydrothide, Hydrozide, Hypothiazid, Hypothiazide, Hyzaar, Idrotiazide, Inderide, Ivaugan, Maschitt, Maxzide, Megadiuril, Microzide, Moduretic, Nefrix, Neo-Codema, Neoflumen, Newtolide, Oretic, Palonyl, Panurin, Perovex, Primogyn, Ro-Hydrazide, Servithiazid, Thiaretic, Thiuretic, Thlaretic, Timolide, Unipres, Urodiazin, Vaseretic, Vetidrex, Ziac, Zide

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