Promethazine review

Promethazine has shown to have various beneficial effects that can treat different types of problems. Find out more about the possible side effects and complications for optimum results.

Promethazine is the generic name of the first generation H1 receptor antagonistic antihistamine and antiemetic prescription drug mainly used as a sedative or hypnotic. The medication also comes under the brand names Promacot, Phenergan and Promethegan. There are several indications for it such as sedation for post-narcotic nausea or pre-surgery, anti-allergy for allergic rhinitis and hay fever and alleviation of cough, pruritus and morning sickness. The drug may also be used together with other medicines to treat anaphylactoid conditions and motion sickness. Promethazine comes in the form of tablets, liquid syrups and suppositories.

Common side effects to expect with Promethazine use would be blurred vision, confusion especially among older patients, fatigue, dizziness, drowsiness, dry mouth, seizure, neuroleptic malignant syndrome, vertigo, respiratory depression among patients below 2 years of age, constipation, euphoria and restless legs. Uncommon side effects include listlessness, nightmares, insomnia, ringing in the ears or tinnitus, double vision, loss of coordination, upset stomach, hyperactivity, stuffy nose and itching. Serious side effects include wheezing, slowed breathing, fever, breathing stops for a short while, sweating, stiff muscles, reduced alertness, confusion, hallucination, uncontrollable shaking of a body part, fainting, unusual bruising or bleeding, sore throat, jaundice, rash, hoarseness and hives.

Contraindications for Promethazine include hypersensitivity to the drug or to phenothiazines, closed angle glaucoma, coma, impaired liver function, alcohol or drug intoxication, enlarged prostate gland and severe hypotension. The drug may also interact with other medications such as amitriptyline, imipramine, antihistamines, anti-Parkinson’s drugs, anti-seizures, anti-anxiety drugs and antidepressants. Children below 2 years old are not allowed to take Promethazine. The doctor should be fully informed about underlying conditions such as history of lung disease, asthma and cancer. Pregnant women or those who intend to get pregnant should also watch intake carefully.

Promethazine acts by blocking histamine H1 receptors without inhibiting histamine secretion thereby producing sedative, anti-emetic, anti-motion sickness and anti-cholinergic effects. By blocking postsynaptic mesolimbic dopaminergic brain receptors, stimuli to the brainstem reticular system are decreased.

27 patients suffering from seasickness were included in a clinical trial wherein were given a total of 25 mg of Promethazine given in 2 or 3 divided doses every day for 2 weeks. At the end of the study, all patients exhibited improvement in their motion sickness condition without suffering any adverse side effects.

Promethazine is a prescription drug in the United States but other countries consider it as an over-the-counter or OTC drug. You may order at local pharmacies or online drugstores but be sure to check product authenticity and source legitimacy.

Those who may be about to undergo surgery or a laboratory test should inform their doctor first about their current intake of Promethazine. The drug may interfere or alter test results including pregnancy tests. Do not let anyone else take the drug and be sure to store it in a tightly sealed container away from children’s reach, moisture and heat.

Promethazine has the following structural formula:

Chemical structure of promethazine

• Molecular formula of promethazine is C17H20N2S
• Chemical IUPAC Name is N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
• Molecular weight is 284.42 g/mol
Promethazine available : 50mg/ml solution 1ml ampule, 50mg suppository, 12.5mg suppository, 6.25mg/5ml syrup, 25mg tablets, 50mg tablets

Brand name(s): Allergan, Aprobit, Atosil, Avomine, Dimapp, Diphergan, Diprazine, Diprozin, Dorme, Duplamin, Fargan, Fellozine, Fenazil, Fenergan, Fenetazina, Genphen, Hiberna, Histargan, Iergigan, Isophenergan, Isopromethazine, Lercigan, Lergigan, Phargan, Phenargan, Phencen, Phenergan, Phensedyl, Pilpophen, Pipolphen, Proazaimine, Proazamine, Procit, Promazinamide, Prometasin, Prometazin, Promethacon, Promethaine, Promethazin, Promethegan, Promethiazine, Promezathine, Prorex, Protazine, Prothazin, Prothazine, Provigan, Pyrethia, Pyrethiazine, Remsed, Romergan, Synalgos, Tanidil, Thiergan, Valergine, Vallergine

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