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Propafenone

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Propafenone

Propafenone review





Patients who are worried about having another arrhythmia attack can rely on Propafenone since it is highly known in increasing the refractory period. Discover the related effects and responses of the drug.

Propafenone is the generic name of the antiarrhythmic drug mainly used to treat problems related to rapid heartbeats such as ventricular and atrial arrhthmias. It also comes under the brand names Rythmol and Rytmonorm which comes in the form of scored tablets to be taken by mouth. Usually the drug is used to prolong the rest period before recurrence of PAF or paroxysmal atrial fibrillation or flutter or PSVT or paroxysmal supraventricular tachycardia both of which can cause debilitating symptoms. Other indications for Propafenone include ventricular tachycardia plus other unlabeled uses.

Like all drugs, Propafenone can cause a number of side effects such as allergic reactions as evidenced by difficulty breathing, swelling of the lips, face or tongue, hives and throat closure, chest pain, shortness of breath, leg or ankle swelling, unusual bruising or bleeding, sore throat, fever, mouth ulcer, infection, blurred vision, dizziness, tiredness, headache, taste changes, upset stomach, vomiting, reduced appetite, constipation, tremors, ataxia, palpitations, body weakness and fatigue. It is possible to have Propafenone overdose may occur as evidenced by slow heartbeats, dizziness, fainting, tiredness, confusion, seizures and irregular heartbeat.

Contraindications for Propafenone include known hypersensitivity to the drug, underlying heart disease, pacemaker, cardiovascular disorder, liver disease, kidney disease, myasthenia gravis, asthma, chronic obstructive pulmonary disease or COPD, cardiogenic shock, manifest electrolyte imbalance, sinoatrial, intraventricular, atrioventricular disorders of impulse conduction or generation, uncontrolled congestive heart failure and other breathing problems. It may also interact with other drugs like quinidine, local anesthetics, cimetidine, cyclosporine, digitalis and warfarin. Special precautions are given to pregnant women and nursing mothers.

Propafenone works by slowing down the influx of sodium ions into the cells of the cardiac muscles thereby resulting to a reduction in cell excitability. As a Class 1C antiarrhythmic drug, refractory period is prolonged as the inward current of sodium ions in myocardial and Purkinje fibers are minimized in terms of velocity. The medication thus depresses triggered responses and automaticity.

A clinical trial was conducted involving 54 patients who had ventricular arrhythmia in the past 6 months. All patients were provided with 500 mg of Propafenone once a day for a duration of 12 weeks. At the end of the study, researchers concluded that concurrent use of the drug resulted to prolonged refractory period in which patients experienced a longer while before symptoms of cardiac arrhythmia and rapid heartbeats related to their condition would again manifest.

Propafenone is readily available in online pharmacies, drugstore and clinics. When buying online, make sure that you check for certification, the expiry date as well as the source. You may want to verify whether the manufacturing company, address and contact number really exist.

Only take Propafenone in the recommended dosage together with a full glass of water although it may be taken with or without food. Do not crush, chew or break the medication but swallow it whole. Make sure you inform your doctor about all underlying conditions, current drugs or herbal treatments you’re taking as well as plans to get pregnant. Store the drug in a tightly sealed container away from heat, moisture and other people’s reach.

Propafenone has the following structural formula:

Chemical structure of propafenone


• Molecular formula of propafenone is C21H27NO3
• Chemical IUPAC Name is 1-[2-(2-hydroxy-3-propylamino-propoxy)phenyl]-3-phenyl-propan-1-one
• Molecular weight is 341.444 g/mol
Propafenone available : 150mg tablets, 225mg tablets, 300mg tablets

Brand name(s): Propafenona, Propafenonum, Rythmol, Rythmol SR

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