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Propulsin

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Propulsin

Propulsin review





Patients with gastrointestinal problems can find relief with Propulsin. The medicament will be quite useful for many for years to come; however, it does have a number of reactions and effects that should be watched for.

Propulsin is a gastrointestinal stimulant used to treat nighttime pyrosis, bowel costiveness and GERD or gastroesophageal reflux disease. It is also known by the brand name Propulsid. Patients not responding well to other treatment and therapies are given Propulsin.

Propulsin is available in a liquid and tablets that should be taken orally. Although the medicament has shown effectiveness in treating bowel disorders, physicians are discouraged from immediately giving the medicament unless other alternatives are ineffective. This medicament was approved by the FDA in 1993 but later was withdrawn in several areas or had limited indications due to reports of arrhythmia and cardiac irregularities.

This medicament is also used in treating megaesophagus and feline megacolon. However, it should not be used for other alternative uses unknown to physicians. It is also useful in treating nausea stemming from motility problems. Propulsin is related to metoclopramide due to their similar effects but the latter is more potent in treating neurological reactions.

Some side effects can result and should be cautiously watched out for. Patients should stop the medicament immediately and report to their physician if symptoms include fainting, allergic reactions, cardiac arrhythmia, chest pain, difficulty breathing and vision changes. Less serious side effects include abdominal pain, diarrhea, costiveness, nausea, urinary frequency, upset stomach, runny nose, cough and headache. Patients may resume taking Propulsin but any side effects must be reported to your physician. Propulsin overdose is possible and symptoms include diarrhea, vomiting, flatulence, tremor, seizure, weakness and nausea. Seek immediate medical attention if you experience any of these symptoms.

Pregnant women and nursing mothers should consult their physician before taking the medicament to discuss potential side effects for the baby. Patients trying to become pregnant should not take the medicament since it can reduce fertility. Propulsin may interact negatively with medicaments like cimetidine, ranitidine, antifungals like ketoconazole, antihistamines, psychoactive medicaments, heart medicaments and benzodiazepines. In the event of intestinal perforation or obstruction, the medicament is contraindicated. Pomegranate juice, tobacco, alcohol, grapefruit juice and red wine are known to reduce the effects and absorption of the medicament in the body. Other contraindications include patients with a history of heart and arterial disease.

Propulsin is a parasympathomimetic medicament acting as an agonist for serotonin 5-HT4 receptors. Once the receptors are stimulated, acetylcholine levels will rise in the enteric nervous system, improving the gastroesophageal condition. The esophageal sphincter also improves with effective gastric emptying.

A clinical trial with 18 patients suffering from GERD were treated with Propulsin and metoclopramide. The participants were divided into two groups. The first group was given Propulsin while the second took metoclopramide. After 7 days, both groups exhibited improvement in gastroesophageal condition. The first group did experience nausea for 1 to 2 days and the second group reported experiencing moderate neurological side effects.

Propulsin is a prescription medicament and should only be purchased from authorized pharmacies. Verify any online pharmacy before purchasing to guarantee authenticity of the medicament.

Propulsin can be taken up to three times daily. Never take more than the prescribed dosage. The medicament should be stored at room temperature away from heat, moisture and out of children's reach. Watch for symptoms of overdose and immediately call for help if anything results. Physicians require laboratory assessment to ensure the safety of the patient while taking the medicament.

Propulsin has the following structural formula:

Chemical structure of propulsin


• Molecular formula of propulsin is C23H29ClFN3O4
• Chemical IUPAC Name is 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide
• Molecular weight is 465.9455 g/mol
Propulsin available : 5mg tablets, 10mg tablets

Generic name: Cisapride

Brand name(s): Acenalin, Alimix, Cipril, Enteropride, Kinestase, Prepulsid, Pridesia, Propulsid, Risamal, Syspride

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