is used to manage erectile dysfunction
through its vasodilatory features and is sold in the United States under the brand name Muse
or Medicated Urethral Suppository for Erection by Vivus. It is also available as Caverject
, which are brand names for its injectable form. Prostaglandin E1 transports the medication as a penile drug delivery system inserted into the urethra
for at least ten minutes before you need an erection. In contrast, the likewise fast-acting Caverject and Edex are injected directly into the penis's corpus cavernosum.
This medicine is recommended for men with erectile dysfunction. You can also use this medication to preserve a patent ductus arteriosus in newborns. This is mostly effective when there is a danger of premature ductus arteriosus closure in a baby with ductal-dependent congenital heart
disease including acyanotic lesions (that is, interrupted aortic arch
, critical aortic stenosis
, hypoplastic left heart syndrome, and coarctation of the aorta).
Prostaglandin E1 is taken as needed to achieve penile erection. The effect starts about five to ten minutes after administration and can last from about thirty minutes to a whole hour. Dosage should be determined by your doctor and you will be examined for any side effects after. Follow the approved instructions precisely. Your doctor should instruct you in detail before trying to administer the medication by yourself. Remember that each product is for single use only and should not be used repeatedly.
Common side effects of Prostaglandin E1 include headache
, flu symptoms, palpitations, dizziness
, minor penile bleeding or spotting, and penile/testicular pain. If any of these adverse effects persist or worsen, consult your doctor immediately. You should also report the very rare but grave side effects of severe unsteadiness or fainting due to possible blood
As for your female partner, know that she may sometimes experience vaginal burning or itching
after sex. It is unclear if this has anything to do with the medication itself. If you experience any other side effects not listed in this article, immediately contact your doctor to discuss them.
Before taking this medication, inform your doctor of all prescription and nonprescription medications you've been taking, especially medicines that can sometimes cause erection problems like MAO inhibitors (furazolidone, selegiline, phenelzine), blood thinners (aspirin, warfarin
, NSAIDs), phenothiazines (chlorpromazine), anti-anxiety medications, calcium
channel blockers or other high blood pressure
medications, hydralazine, terazosin
, guanabenz, disopyramide
, thiazide water pills, methyldopa, spironolactone
, and tricyclic antidepressants. Do not start or stop taking any medicine without prior doctor consent.
Inform your doctor of your medical history before taking this medication, especially if you have any history of allergies
, prolonged erections from other medications, cancer
, physical penis
abnormalities, blood or bleeding disorders, low blood pressure, or heart disease. You should also be aware that this medication offers zero protection against sexually transmitted infections such as Hepatitis B
Overdosing with Prostaglandin E1 can lead to experiencing a painful and persistent erection for hours on end. If left untreated, this can cause you to have a permanent inability to have an erection. Seek emergency medical attention if you experience a prolonged and agonizing erection after using this medication.
Prostaglandin e1 has the following structural formula:
• Molecular formula of prostaglandin e1 is C20H34O5
• Chemical IUPAC Name is 7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)-5-oxo-cyclopentyl]heptanoic acid
• Molecular weight is 354.481 g/mol
• Prostaglandin e1 available : 500mg tablets