Prostigmin review

Prostigmin is a medication manufactured by Valeant Pharmaceuticals International used primarily in the treatment of myasthenia gravis (MG). It is also used to treat urine retention conditions and gut function problems. Neostigmine, Prostigmin’s active ingredient, treats MG by preventing the loss of acetylcholine in the body. Acetylcholine is an essential component for the transmission of nerve impulses within the muscle that is lost in patients with MG. This is allows for improved muscle function. Prostigmin is available as ampoules or in the form of tablets. The injectable ampoules are used for more severe case of MG when swallowing is difficult or for treatment of intestinal or urinary disorders while the tablets are designed for progressive treatment of MG.

Treatment varies from each patient, so the doctor will be able to prescribe his own dosage for you. Usually taken several times through out the day it may be taken with or without food. A typically adult dosage would be around 15mg each dose every three to four hours amounting to 70mg but never more than 375mg for the whole day. Larger doses may be given during peak hours of fatigue.

Never take double the dose in order to make up for a skipped dose. Skip it and proceed to the next dose. Always follow exactly the doctor’s prescription to achieve maximum effect.

Do not take Prostigmin if you are known to have peritonitis, intestinal or urinary blockage or if you have any sensitivity or allergy to Prostigmin. Care should also be taken and consult your doctor if you suffer from low blood pressure, asthma, heart, thyroid or kidney conditions, Parkinson’s disease, epilepsy, had a recent cardiac arrest or have a slow heart rate. Caution should also be taken by pregnant or breastfeeding mothers when planning to take this medication, as its effects on the child are still inconclusive but may still pose an unnecessary risk.

Inform your doctor your use of Prostigmin prior to surgery as anesthesia may interfere with the drugs function. Antibiotics such as neomycin, streptomycin and kanamycin should only be taken when absolutely necessary as these may also interfere with Prostigmin. Prostigmin may also interact with antiarrhythmia medications and drugs that regulate stomach movement. Corticosteroid use may also require an adjustment of Prostigmin dosage. Medications such as calcium channel blockers and beta-blockers without ISA may also increase the risk for slow heart rate.

Prostigmin should not be used with muscle relaxants such as suxamethonium as this may lead to difficulties in breathing.

It is not unusual for you to experience muscle twitching, abdominal pain, nausea, diarrhea or excess salivation as an effect of taking Prostigmin but if these effects persist and becomes bothersome, consult your doctor. Always watch out for an allergic reaction to this drug. Atropine and epinephrine may be necessary in order to treat hypersensitivity to Prostigmin. You may also experience excess urination while starting treatment.

Serious side effects include muscle weakness, vision problems, cramps, irregular heartbeat (more common with the injected form of Prostigmin), confusion, dizziness and shortness of breath.

Prostigmin has the following structural formula:

Chemical structure of prostigmin

• Molecular formula of prostigmin is C12H19N2O2
• Chemical IUPAC Name is [3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium
• Molecular weight is 223.2915 g/mol
Prostigmin available : 15mg tablets

Generic name: Neostigmine

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