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Protopic

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Protopic

Protopic review





Protopic, which is generically prescribed as tacrolimus topical, is commonly used to treat atopic dermatitis, which is also known as eczema. Protopic slows the growth of atopic dermatitis on the skin. Protopic is usually a treatment choice when other treatment options have failed to work well for the patient.

Protopic is not appropriate for everyone. A thorough medical history should be assessed prior to prescribing this medication. Patients with a medical history which includes skin cancer, skin infection, chicken pox, herpes, Netherton’s syndrome, a weakened immune system, kidney disease, or large areas of redness, swelling, or irritation of the skin’s surface may not be able to take Protopic or may require careful monitoring while undergoing drug therapy with this medication, depending on the condition and the severity of the condition. Protopic is not appropriate for children under the age of 2 years old.

The American Food and Drug Administration rated Protopic as a pregnancy risk category C. This medication has proven to cause harm or birth defects in unborn babies. Protopic has been proven to pass through the mother’s breast milk and may affect a nursing baby. The prescribing physician should avoid using this medication with women who are pregnant, nursing, or have a high likelihood of becoming pregnant.

There is a risk of side effects associated with Protopic, some of which are severe. A patient who is experiencing a serious side effect or an allergic reaction should seek immediate emergency medical attention. An allergic reaction will present with side effects such as facial swelling, including swelling of the lips, mouth, throat, or tongue, hives, and difficulty breathing. Other serious side effects which require immediate emergency medical attention include symptoms such as fever, chills, body aches, flu symptoms, signs of skin infection, worsening skin symptoms, and swollen glands.

Less serious side effects typically do not require emergency medical attention but should be reported to the prescribing physician. Patients should be encouraged to report all side effects. Less serious side effects include symptoms such as swollen hair follicles, acne, upset stomach, muscle pain, burning, stinging, soreness of treated area, headaches, and increased sensitivity to temperatures. Less serious side effects can often be reduced to a tolerable level by reducing the dosage of Protopic.

Protopic should be taken exactly as it has been prescribed by the physician. If the patient misses a dose, the dose should be taken as soon as it is remembered. However, if it is almost time for the next scheduled dose, the missed dose should be skipped to avoid the potential for an overdose. The patient should never take a double dose of this medication. If an overdose is suspected, the patient should seek immediate emergency medical attention. An overdose will present with symptoms such as severe skin irritation, numbness, or the sensation of being burning cold.

There is a potential risk of negative drug interactions associated with Protopic. A thorough medical history should be understood prior to prescribing this medication. Patients should be urged to inquire with the prescribing physician before taking any new medications, including over the counter medications and herbal remedies. Medications with a known negative drug interactions with Protopic include cimetidine, erythromycin, heart medication, and antifungal medications. Additional skin treatments or topicals should be avoided unless prescribed by the physician. Patients should be urged to use caution when sun exposure may occur. Although rare, Protopic has been associated with some cases of skin cancer.

Protopic has the following structural formula:

Chemical structure of protopic


• Molecular formula of protopic is C44H69NO12
• Chemical IUPAC Name is [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]- 5,6,8,11,12,13,14,15, 16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3- [2-(4-hydroxy-3-methoxycyclohexyl) - 1-methylethenyl]-14, 16-dimethoxy-4,10,12,18-tetramethyl-8- (2-propenyl)-15, 19-epoxy-3H-pyrido[2,1-c][1,4] oxaazacyclotricosine-1,7,20, 21(4H,23H)-tetrone, monohydrate
• Molecular weight is 804.018 g/mol
Protopic available : 0.1% ointment, 0.03% ointment 30gm tube, 0.1% ointment 30gm tube, 0.1% ointment 60gm tube

Generic name: Tacrolimus

Brand name(s): Prograf, Tacarolimus

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