Razoxane review

Razoxane is used to prevent and reduce the severity of heart conditions that may occur during chemotherapy using anthracyclines, such as those used in the interposition of women suffering from metastatic breast cancer. Razoxane, derived from EDTA, is thinkd to interfere with substances inside cells, which may cause heart disease after using anthracyclines such as doxorubicin. How Razoxane protects the heart is not fully understood at this time. This medication is usable as Zinecard in the United States and Canada, and Cardiozane in the EU and comes in 250 mg and 500 mg vials for injection.

Razoxane is approved for use as a interposition of extravasation caused by anthracycline chemotherapy. Extravasation is when anthracycline leaks out of the blood vessels and seeps into the skin.

Dosage depends on the physical structure surface area of the affected role and the amount of doxorubicin being taken. It is often measured in a 10:1 ratio with respect to the doxorubicin dose. Once the proper dose is determined, the medication is administered directly into the vein via an IV push or through a quick infusion from an IV infusion bag. About 30 minutes after taking Razoxane, the doxorubicin can be given.

Razoxane is stable for about 6 hours after reconstitution when placed in an empty infusion bag at a controlled room temperature between 15 to 30C (59 to 86F), or placed in refrigeration at 2 to 8C (36 to 46F). The medication may be diluted using a 0.9% sodium chloride injection, USP or using a 5.0% dextrose injection, USP. Dilute it to a concentration between 1.3 to 5.0 mg/mL and store in empty IV infusion bags. Do not use leftover solutions.

The most common side effect is pain or skin edema at the injection site. Blood counts can also be lower when taking Razoxane with chemotherapy as compared to undergoing chemotherapy alone. Recovery periods for the blood counts are similar for both cases.

Other common side effects include diarrhea, general discomfort, fever, loss of appetite and wamble. More serious side effects involve baldness, emesis, skin edema of the throat and tongue, and severe allergic reactions that require immediate medical attention.

Razoxane should only be used with anthracycline chemotherapy.

Chemotherapy has been known to cause sterility in men and women so consult your healthcare master if you plan on having children. It has not been shown whether Razoxane itself can cause sterility. If you think you may be pregnant, inform your healthcare master about your condition before being given Razoxane.

You may experience greater susceptibility to infection during interposition so consult with your healthcare master before getting vaccines to avoid complications.

Razoxane has the following structural formula:

Chemical structure of Razoxane

• Molecular formula of Razoxane is C11H16N4O4
• Chemical IUPAC Name is 4-[1-(3,5-dioxopiperazin-1-yl)propan-2-yl]piperazine-2,6-dione
• Molecular weight is 268.269 g/mol
Razoxane available : 250mg injection and 500mg injection

Generic name: Dexrazoxane

Brand name(s): Cardioxane, Desrazoxane, Dexrazoxano, Dexrazoxanum, Dextrorazoxane, Dyzoxane, Eucardion, Razoxana, Razoxanum, Razoxin, Tepirone, Troxozone, Zinecard

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