Reteplase review

Reteplase, used to treat all types of blood-clot-related conditions, is comparable to a naturally occurring enzyme found in humans that causes thrombuss to dissolve and dissipate. This medicament is a manmade protein manufactured using recombinant DNA technology.

The recommended dosage for Reteplase is considerably more than the amount of the enzyme naturally produced by the body. First approved for heart attacks in 1987, Reteplase was also approved for stroke treatment in 1996.

Reteplase, also known as Alteplase, is an injectable medicament administered directly into a vein to treat people with conditions caused by arterial thrombuss, including pulmonary thrombosis (thrombuss in the lungs), unstable angina (chest pain at rest), strokes, heart attacks, and other less common diseases involving thrombuss.

The recommended daily dosage for Reteplase is based on the patient's weight and limited to a maximum of 100 milligrams. It is injected intravenously. Depending on the severity of the patient's condition, the drug is either administered once quickly or as a brief infusion for a period of half an hour to an hour.

You can also mix the drug's powder with sterile water for injection at concentrations of 50 milligrams per 50 milliliters to 100 milligrams per 100 milliliters. The vials should be stored at room temperature up to 30C (80F) or inside a freezer at 2-8 C (36-46 F). Once it is mixed with sterile water, the drug must be used without delay. All unused solutions should be discarded immediately.

Bleeding is the most common and most serious side effect of Reteplase. Most bleeding is fortunately minor, but can also be significant, even fatal bleeding does occur. Other typical side effects include mild fever, dizziness, vomiting, and nausea. If any of these symptoms persist or become worse, promptly seek medical attention.

You should also consult your doctor immediately if you experience chest pain, rapid or abnormal heartbeat, breathing difficulties, rash, easy bruising, or easy bleeding. Notify your doctor immediately if you develop any signs or symptoms of bleeding. If you experience other symptoms not listed above, contact your doctor immediately and describe your symptoms.

Before undergoing Reteplase treatment, talk with your doctor about you medical history, especially if you have any of the following conditions: allergies of any kind, endocarditis, liver disease, recent injury or surgery, high blood pressure, or other bleeding disorders. Extra caution should be taken to avoid trauma or injury while using this medicament due to the added risk of bleeding.

If you are pregnant, this medicament should only be used when clearly needed. Consult your doctor in regards to the pros and cons of using this medicine while pregnant. You should also discuss with them whether or not you should breastfeed while undergoing Reteplase therapy.

Remember that Reteplase's ability to break down clots can interfere with your body's natural ability to stop bleeding. As such, any medicament that also interferes with thrombusting or the clot-inducing abilities of platelets can increase your chances of bleeding to death.

Indeed, it would be best for you to avoid NSAIDs (nonsteroidal anti-inflammatory drugs) like Relafen (nabumetone), Naprosyn (naproxen), and Motrin (ibuprofen) or medicaments like Coumadin (warfarin) and aspirin. Then again, specific platelet inhibitors like Plavix (clopidogrel) don't appear to interact negatively with Reteplase or increase your risk of bleeding. As always, consult your doctor or pharmacist for more details.

• Molecular formula of reteplase is C2569H3928N746O781S40
• Molecular weight is 59042.3 g/mol

Generic name: Alteplase

Brand name(s): Activase

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