Retin-A review

Retin-A, which is generically prescribed as tretinoin topical, is commonly used to treat Acne, fine wrinkles, skin mottling or discoloration, and the effects of over exposure to the sun. Retin-A often takes many weeks before results or improvement begins to show. Often appearance of the skin can worsen before improving.

Retin-A is not appropriate for everyone. A thorough medical history should be assessed prior to prescribing this medication. Patients with a medical history which includes skin diseases, skin sensitivities, open sore, chapped skin, sunburn, or wind burn may not be able to take Retin-A or may require careful monitoring while undergoing drug therapy with this medication, depending on the condition and the severity of the condition.

The American Food and Drug Administration rated Retin-A as a pregnancy risk category C. Retin-A has been proven to cause harm or birth defects in unborn babies. Retin-A has also been proven to pass through the mother’s breast milk and may affect a nursing baby. The prescribing physician should avoid using this medication for women who are pregnant, nursing, or have a high likelihood of becoming pregnant.

There is a risk of side effects associated with Retin-A, some of which are severe. A patient who is experiencing a serious side effect or an allergic reaction should seek immediate emergency medical attention. An allergic reaction will present with side effects such as facial swelling, including swelling of the lips, mouth, throat, or tongue, hives, and difficulty breathing. Other serious side effects which require immediate emergency medical attention include symptoms such as intolerable sensations of burning or stinging, or numbness of the facial skin.

Less serious side effects typically do not require emergency medical attention but should be reported to the prescribing physician. Patients should be encouraged to report all side effects. Less serious side effects include symptoms such as redness, irritation, burning, itching, peeling, flaking, warmth, discoloration of the skin, drying, swelling, or tingling. Less serious side effects can often be reduced to a tolerable level by reducing the dosage of Retin-A.

Retin-A should be taken exactly as it has been prescribed by the physician. If the patient misses a dose, the dose should be taken as soon as it is remembered. However, if it is almost time for the next scheduled dose, the missed dose should be skipped to avoid the potential for an overdose. The patient should never take a double dose of this medication. If an overdose is suspected, the patient should seek immediate emergency medical attention. An overdose will present with symptoms such as a sensation of burning cold, or intolerable burning or stinging.

There is a potential risk of negative drug interactions associated with Retin-A. A thorough medical history should be understood prior to prescribing this medication. Patients should be urged to inquire with the prescribing physician before taking any new medications, including over the counter medications and herbal remedies. Medications with a known negative drug interactions with Retin-A include sulfa medication, tetracycline, diuretics, antibiotics, and chlorpromazine. Patients should be urged to refrain from sun exposure as this may result in serious and fast sunburns. Patients should avoid using other topical medications or treatments unless directed to do so by a physician. Other skin products such as harsh cleansers, cosmetics, and perfumes may contribute to irritation of the skin while undergoing drug therapy with Retin-A.

Retin-a has the following structural formula:

Chemical structure of retin-a

• Molecular formula of retin-a is C20H28O2
• Chemical IUPAC Name is 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,6,8-tetraenoic acid
• Molecular weight is 300.435 g/mol
Retin-a available : 0.025% cream 20gm tube, 0.05% cream 20gm tube, 0.1% cream 20gm tube, 0.025% cream 45gm tube, 0.05% cream 45gm tube, 0.1% cream 45gm tube, 0.025% gel 15gm tube, 0.01% gel 45gm tube, 0.025% gel 45gm tube

Generic name: Alitretinoin

Brand name(s): Avita, Beta-retinoic acid, Panretin, Panretyn, Panrexin, Renova, Retinoate, Retinoic acid, Trans-Retinoic acid, Tretinoin, Vesanoid, Vitamin A acid

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