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Rifampin

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Rifampin

Rifampin review





Rifampin is a medication that kills Tuberculosis-causing bacteria. It also helps prevent the patient from spreading the infection to other people. Rifampin is not administered alone. It is normally given together with three other drugs.

Rifampin is available as a capsule that should be taken orally. It can be taken in either 150mg or 300 mg doses, depending on the doctor’s instructions. In order to maximize Rifampin’s effects, it must be taken once a day for a period that can be as short as 3 months and as long as two years. Rifampin is given over an extended period of time in order to make sure that the bacteria is totally eradicated and the patient is no longer contagious. Rifampin works best when it is taken on an empty stomach so make sure you take it one or two hours before your next meal.

Rifampin can also be injected to the body. However, this can only be done by a medical professional.

Rifampin tends to affect the function of oral contraceptives so it is advisable that you opt for another form of birth control.

To prevent negative drug interactions, inform your doctor about any other medication that you are currently taking. Inform your doctor about taking medications for heart disease, for blood thinning, for hormone replacement and for diabetes. HIV or AIDS medication will also interact negatively with Rifampin. Barbiturates may also produce adverse effects. Also, inform your doctor about any vitamins or food supplement that you are currently taking.

Rifampin has a tendency to dramatically reduce the effect of anticoagulants. As a result, blood clots may occur. In order to prevent this, doctors sometimes raise to dosage of anticoagulants to three times the normal amount. This is done in order to counter Rifampin’s effects.

If you have a history of liver disease, the doctor may need to adjust your dosage in order to prevent further liver damage. In some cases, Rifampin is so potent that patients get a bit of jaundice. In very severe cases, the liver damage is so extensive, it leads to death.

In addition, if you get pregnant while taking this medication or if you are breastfeeding, contact your physician immediately. He will decide whether it is safe for you and your baby to continue the treatment.

When you start taking Rifampin, there will be a marked difference with the appearance of your body excretions. Your tears, saliva, sweat, stool and urine may turn into a red-orange color. However, this is normal and is not at all indicative of any harm from the Rifampin treatment.

The patient may also feel pain in the muscle and in the bones. Stomach cramps, vomiting and diarrhea may also be experienced. Chills or heartburn can also happen.

It is also possible for the patient to have an allergic reaction to Rifampin. If the patient breaks out in hives and gets rashes all over the body, it might be the sign of an allergic reaction. Swelling of the face, legs and arms could also be a sign. Difficulty in breathing may be part of the symptoms.

Rifampin has the following structural formula:

Chemical structure of rifampin


• Molecular formula of rifampin is C43H58N4O12
• Chemical IUPAC Name is (7S,9E,11S,12S,13R,14S,15R,16S,17R,18S,26E)-2,15,17,29- tetrahydroxy-11-methoxy-3,7, 12,14,16,18,22-heptamethyl-26-{[(4-methylpiperazin-1-yl)amino]methylidene}-6,23,27- trioxo-8,30-dioxa-24- azatetracyclo[23.3.1.1^{4,7}.0^{5,28}]triaconta-1(28),2,4,9,19,21,25(29)- heptaen-13-yl acetate
• Molecular weight is 822.9402 g/mol
Rifampin available : 150mg tablets, 300mg tablets and 600mg tablets

Brand name(s): Archidyn, Rfamipicin, Rifa, Rifadin, Rifadine, Rifagen, Rifaldazin, Rifaldazine, Rifaldin, Rifamate, Rifampicin, Rifamycin, Rifaprodin, Rifater, Rifoldin, Rifoldine, Riforal, Rimactan, Rimactane, Rimactin, Rimazid, Rofact, Tubocin

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