Simvastatin review

Simvastatin is a generic medication that also goes by the brand names Vytorin and Zocor. It belongs to a class of medications called statins, or HMG-CoA reductase inhibitors, which work to lower lipids, or fats, in the blood stream. It works by inhibiting the production of cholesterol in the body. Lower levels of cholesterol can help facilitate the flow of blood, which brings oxygen to your heart, brain, and other parts of your body. Simvastatin is used in conjunction with changes in your diet and lifestyle. These changes include a low-cholesterol, low-fat diet, exercise and weight loss, to help prevent heart disease, angina, strokes, and heart attacks. It is prescribed in tablet form and taken one to three times per day.

Simvastatin, like all medications, may cause side effects. The most common side effect is constipation, which usually goes away after your body has time to adjust to the medication. You may also experience abdominal pain, upper respiratory tract infections or headache. Other very serious side effects include muscle pain or tenderness, muscle weakness, malaise or flu-like symptoms, fever, jaundice, pain in the upper right part of the stomach, nausea or vomiting, loss of appetite, unusual bleeding or bruising, rash or hives, itching, difficulty breathing, difficulty swallowing, hoarseness, or swelling of the face, throat, tongue, lips, hands, feet, or ankles. If you experience any of these reactions to Simvastatin, call your doctor immediately.

There are some medications and conditions that should be avoided or approached cautiously if you intend to take Simvastatin. Make sure your doctor knows if you are taking any other medications, especially blood thinners such as Coumadin, antifungal medications such as Sporanox, Cordarone or Pacerone, Nizoral, Questran, Biaxin, Atromid-S, cyclosporines such as Sandimmune or Neoral, HIV protease inhibitors, niacin, or other cholesterol-lowering medications. Your doses may need to be monitored if you are combining Simvastatin with any of these. If you have liver disease, if you drink large amount of alcohol, or if you have kidney disease, your doctor will probably choose to treat you with something besides Simvastatin. You should avoid drinking alcohol during this treatment since it can make your side effects worse, raise your triglycerides, and possibly damage your liver.

Simvastatin in in Pregnancy Category X, which means that you should not take it while you are pregnant. It has been shown to cause birth defects, deformities, or even death to developing fetuses. If you are a woman of childbearing age, you must be using an effective form of birth control, and if you become pregnant while taking Simvastatin, you should stop taking it immediately. It is not known whether Simvastatin passes into breast milk, but other drugs of this class are known to do so, so you should avoid nursing your baby while you are taking Simvastatin. Simvastatin is safe and effective for children over the age of ten, and in girls at least a year over the onset of menstruation, but it is not indicated in children younger than that.

Simvastatin has the following structural formula:

Chemical structure of simvastatin

• Molecular formula of simvastatin is C25H38O5
• Chemical IUPAC Name is [(1S,3R,7R,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]-3,7- dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
• Molecular weight is 418.566 g/mol
Simvastatin available : 5mg tablets, 10mg tablets, 20mg tablets, 40mg tablets, 80mg tablets

Brand name(s): Cholestat, Coledis, Colemin, Corolin, Denan, Labistatin, Lipex, Liponorm, Lodales, Medipo, Nivelipol, Pantok, Rendapid, Simovil, Simvastatina, Simvastatine, Simvastatinum, Sinvacor, Sivastin, Synvinolin, Vasotenal, Vytorin, Zocor, Zocord

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