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Tacrolimus

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Tacrolimus

Tacrolimus review





Tacrolimus is an immunosuppressant drug. It is used to lessen the ability of your immune system. This is required in cases where organ transplant has taken place. Our body s immune system is always alert in fighting foreign objects, which make up its wonderful ability to fight infections. On a bad aspect, it can also reject the entry of a transplanted organ such as kidney or liver. That is why Tacrolimus is supplied to patients who just underwent transplant. It lowers the activity of the immune system, making it easier for the organ to blend in your system.

Tacrolimus is also used to suppress the outbreak of ulcerative colitis. It has been found effective in controlling the inflammation caused by a bowel disease.

There is also a topical form of Tacrolimus that is used to treat eczema and other skin conditions. It works similarly to steroids in suppressing skin inflammation, only better.

Before using Tacrolimus, it is important that you settle important factors with your doctor. Discuss your allergies, medical history, and current drug intake.

An allergy to castor oil and similar components are of special concern. Tell your doctor of your other allergies than those related to drugs.

Tacrolimus must also be used with caution in patients with high blood pressure, kidney disorders, and liver ailments. If you suffer from any of those conditions, you might need a dosage adjustment or a different drug altogether.

Also, Tacrolimus may be harmful to an unborn child. Do not use this medication in pregnant women and those who are nursing a newborn. If it is truly needed, ask your doctor about what you can do to lessen the risks.

Aside from topical versions, Tacrolimus is also available in capsule and injectable forms. It is important for patients who just had a transplant to take Tacrolimus regularly. The immunosuppressive effect only lasts if you continue taking the medication. Make sure that you take your medicine every twelve hours or twice a day. To be sure, take your medication at the same time each day so you reduce the risk of missing out on a dose. If Tacrolimus is not active in your body, your immune system may start attacking the transplanted organ.

Tacrolimus must be taken continuously until your doctor tells you otherwise. Never stop your medication without getting instructions from your doctor.

While under Tacrolimus treatment, avoid taking grapefruit or grapefruit juice. Grapefruit may pose a dangerously adverse reaction with Tacrolimus.

Tacrolimus may also increase your chance of contracting cancer, especially skin cancer. If your immune system is suppressed for a long period of time, you naturally have low defenses against infection and other health risks. To make yourself safe from skin cancer while undergoing Tacrolimus therapy, avoid exposure to artificial UV rays and sunlight.

In some cases, Tacrolimus has also been found relative in patients who underwent a kidney transplant and developed diabetes. With such a risk and all the other risks mentioned above, you must remember to take Tacrolimus under strict supervision.

Tacrolimus may cause mild skin rash, insomnia, appetite loss, nausea, and vomiting. Such symptoms, however, must be temporary. If they persist or came with more serious conditions such as urination problems, tremor, muscle weakness, and flu-like symptoms, call your doctor immediately.

Tacrolimus has the following structural formula:

Chemical structure of tacrolimus


• Molecular formula of tacrolimus is C44H69NO12
• Chemical IUPAC Name is [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]- 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3- [2-(4-hydroxy- 3-methoxycyclohexyl) -1-methylethenyl]-14, 16-dimethoxy-4,10,12,18-tetramethyl- 8-(2-propenyl)-15, 19-epoxy-3H-pyrido[2,1-c][1,4] oxaazacyclotricosine-1,7,20, 21(4H,23H)-tetrone, monohydrate
• Molecular weight is 804.018 g/mol
Tacrolimus available : 0.5mg capsules, 1mg capsules, 5mg capsules

Brand name(s): Prograf, Protopic, Tacarolimus

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