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Targretin

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Targretin

Targretin review





Targretin is an anticancer medication specifically created for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer. It works by inhibiting the rampant growth of cells inside neoplasms, preventing them from growing out of control and turning into full tumors. Targretin binds to the DNA of these cells and interferes with their development and reproduction. Itcan be used in the treatment of other cancers such as Kaposi's sarcoma, breast cancer and lung cancer.

Targretin comes in both 75 mg soft capsules, to be taken orally, and as a 1% topical gel.

Targretin is prescribed to patients suffering from CTCL, especially those who have shown little progress with at least one other medication or therapy. The topical gel is used to relieve the red, itchy skin lesions experienced by CTCL patients. The oral capsules are also used to treat CTCL, but can also be used to treat other cancers, such as those affecting the blood cells and lymph nodes.

Whether you are taking the oral capsules or applying the topical gel, always read the instructions supplied with the medication and follow the specific instructions given by your doctor.

The topical preparation of Targretin is usually applied once every other day. The doctor can gradually adjust your dose depending on your progress, but usually not more than once every week. Dosage may be increased and the gel applied more frequently, up to four times in a day. The doctor may also opt to lower your dose when you experience side effects. Improvements of your condition may be apparent in as soon as 4 weeks but it may also take months before any real improvement can be observed. Do not discontinue use of Targretin without consulting your doctor.

As Targretin gel may catch fire, avoid applying the topical medication while smoking or near sources of heat. The gel is strictly for external use only. Do not ingest the topical gel and keep it away from sensitive areas such as your eyes, nostrils, lips and mouth, and the anal and genital area.

Bathing and swimming is allowed even when applying topical Targretin, but take care to use only mild soaps and wait at least 20 minutes after taking a bath or swimming before applying the medication. After you apply the medication, do not bathe, swim, or shower for at least 3 hours.

When applying the gel, make sure both your hands and the affected area is clean. Avoid getting the gel onto healthy skin and do not rub the gel into the skin. Instead, leave a thin layer on top of the affected area. Avoid wrapping the affected area in a tight bandage or clothing after applying the medicine. Wipe your hands clean and wash with soap and water.

For the oral preparation of Targretin, the doctor will give specific dose information for you depending on your medical history and your condition. Follow all instructions very carefully and consult your doctor regarding any changes.

Swallow all capsules in the prescribed dose together, and take care not to break or chew on them. If a capsule is found to be broken, do not touch with your hands and do not attempt to take them anyway. Continue treatment even if you do not see immediate results, unless the doctor instructs you to stop.

When taking Targretin orally, some side effects include headache, fatigue, dryness of skin, weakness, nausea, diarrhoea, or some rashes and skin edema. Doctors may also monitor your blood triglyceride and cholesterol levels as some patients experience a rise of these substances in their blood while on Targretin.

A more serious reaction involving Targretin that needs medical attention is pacreatitis. Its symptoms include persistent nausea and emesis, as well as both abdominal or dorsalgia.

The topical preparation may cause skin irritation in certain patients, and patients can suffer allergic reactions from both.

Targretin is found to be potentially harmful for developing fetuses and has been shown to cause birth defects in rats. If you are planning to have sexual intercourse, use multiple contraceptives involving chemical and barrier methods to prevent conception. Even males who are on Targretin must wear condoms and use other barrier methods until at least one month after the last dose taken.

Targretin has the following structural formula:

Chemical structure of targretin


• Molecular formula of targretin is C24H28O2
• Chemical IUPAC Name is 4-[1-(3,5,5,8,8-pentamethyltetralin-2-yl)ethenyl]benzoic acid
• Molecular weight is 348.478 g/mol
Targretin available : 75mg capsules

Generic name: Bexarotene

Brand name(s): Targret, Targretyn, Targrexin

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