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Targrexin

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Targrexin

Targrexin review





Targrexin is an anticancer medicament specifically created for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer. It works by inhibiting the rampant growth of cells inside neoplasms, preventing them from growing out of control and turning into full tumors. Targrexin binds to the Deoxyribonucleic acid of these cells and interferes with their development and reproduction. Itcan be used in the treatment of other cancers such as Kaposi's sarcoma, breast cancer and lung cancer.

Targrexin comes in both 75 mg soft capsules, to be taken orally, and as a 1% topical gel.

Targrexin is prescribed to patients suffering from CTCL, especially those who have shown little progress with at least one other medicament or therapy. The topical gel is used to relieve the red, itchy skin lesions experienced by CTCL patients. The oral capsules are also used to treat CTCL, but can also be used to treat other cancers, such as those affecting the blood cells and lymph nodes.

Whether you are taking the oral capsules or applying the topical gel, always read the instructions supplied with the medicament and follow the specific instructions given by your doctor.

The topical gel is usually applied once every other day. The doctor may gradually adjust your dose depending on your progress, but usually will not adjust your dose more than once every week. Dosage may be increased and the gel applied more frequently, up to four times a day. The doctor may opt to lower your dose if you experience side effects. Improvements of your condition may be apparent in as soon as 4 weeks but it may take months before any real improvement is observed. Do not discontinue use of Targrexin without consulting your doctor first.

Since Targrexin gel may catch fire, avoid applying the topical medicament while smoking or near sources of heat. The gel is strictly for external use only. Do not ingest the topical gel and keep it away from sensitive areas such as your eyes, nostrils, lips and mouth, and the anal and genital area.

Bathing and swimming are allowed even when applying topical Targrexin, but take care to use only mild soaps and wait at least 20 minutes after taking a bath or swimming before applying the medicament. After you apply the medicament, do not bathe, swim, or shower for at least 3 hours.

When applying the gel, make sure both your hands and the affected area is clean first. Avoid getting the gel onto healthy skin and do not rub the gel into the skin. Instead, apply a thin layer on top of the affected area. Avoid wrapping the affected area in a tight bandage or clothing after applying the medicine. Wipe your hands clean and wash them with soap and water after applying the medicament.

When taking the capsules, the doctor will give specific dose information to you depending on your medical history and your condition. Follow all instructions very carefully and consult your doctor regarding any changes.

Swallow all capsules in the prescribed dose together, taking care not to break or chew on them. If a capsule is broken, do not touch it with your hands and do not attempt to take it. Dispose of it immediately. Continue treatment even if you do not see immediate results, unless the doctor instructs you otherwise.

Some side effects of the capsule include headache, exhaustion, dryness of skin, weakness, nausea, diarrhea, or some rashes and swelling. Your doctor may monitor your blood triglyceride and cholesterol levels as some patients experience a rise of these substances in their blood while on Targrexin.

A more serious reaction that needs medical attention is pacreatitis. Its symptoms include persistent nausea, emesis, and abdominal or back pain.

The topical gel may cause skin irritation in certain patients, and patients may suffer allergic reactions from both.

Targrexin is potentially harmful to developing fetuses and has been shown to cause birth defects in rats. If you are planning to have sexual intercourse while taking this medicament, use multiple contraceptives involving chemical and barrier methods to prevent conception. Even males who are on Targrexin must wear condoms and use other barrier methods until at least one month after the last dose is taken.

Targrexin has the following structural formula:

Chemical structure of targrexin


• Molecular formula of targrexin is C24H28O2
• Chemical IUPAC Name is 4-[1-(3,5,5,8,8-pentamethyltetralin-2-yl)ethenyl]benzoic acid
• Molecular weight is 348.478 g/mol
Targrexin available : 75mg capsules

Generic name: Bexarotene

Brand name(s): Targret, Targretin, Targretyn

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