Used mainly to treat the symptoms of schizophrenia—a mental illness that causes unusual thinking, depression
, and strong but inappropriate emotions—thioridazine
is usually used on patients that have already tried two other schizophrenia
medications but were not able to get any significant improvement from their sickness
. It belongs to a group of drugs called conventional antipsychotics, and it works by lessening abnormal activity in the brain
The dosage of thioridazine needed for maximum therapeutic effect depends on the given patient. As such, each dose must be adjusted to suit an individual's particular physiology or metabolism. As a rule of thumb, the usual initial dosage for adults is fifty to a hundred milligrams three times a day. This can be steadily increased to a maximum of eight hundred milligrams daily.
Once the desired curative effect has been attained, the thioridazine dosage should be stabilized and made more consistent. For maintenance purposes, a dosage of two hundred to eight hundred milligrams per day given in three to four doses should be sufficient. As always, consult your doctor for the correct thioridazine dosage most suitable for you.
Check with your doctor or pharmacist if you are allergic to thioridazine or other phenothiazines like prochlorperazine
, perphenazine, fluphenazine, trifluoperazine, promethazine
, and chlorpromazine. It is also wise to inform your doctor about what prescription and nonprescription drugs you're taking or planning to take, even if they're just nutritional supplements, herbal products, or vitamins.
Be sure to mention if you're taking any of the following medications before undergoing treatment: antihistamines, epinephrine, ipratropium
, antidepressants, secobarbital, phenobarbital, atropine
, pentobarbital, sedatives, narcotic medications for pain, sleeping pills, tranquilizers, and barbiturates such as medications for anxiety
or mental illness, Parkinson's disease, motion sickness
, seizures, irritable bowel disease, ulcers, or urinary problems. Depending on what medication you are on or planning to be on, your doctor may need to change your thioridazine dosage or observe you carefully for any side effects.
In turn, you also need to consult your doctor if you are pregnant, plan to be pregnant, or are breastfeeding before you start taking thioridazine. If you do get pregnant in the middle of thioridazine treatment, consult your doctor immediately. In addition, you need to tell your doctor or dentist if you're taking thioridazine before having surgery, even minor surgery like teeth
It is also important to be aware of the fact that this drug can cause drowsiness and may affect your movements and thinking. Ergo, tell your doctor if you need to drive a car or operate heavy machinery while under medication. Your dosage may need to be adjusted accordingly depending on all these factors. Finally, consult your doctor about the safe use of alcohol while under thiordazine treatment, because alcohol is known to make the side effects of this drug worsen.
As mentioned, the most common side effect of thioridazine is lack of physical and mental alertness caused by drowsiness. This side effect manifests itself early on in therapy, so patients should avoid performing dangerous tasks that involve their full mental alertness or hand-and-eye coordination.
This medication's other side effects are increased risk of serious sunburn due to greater sensitivity to the sun, constipation
, urinary retention, and dry mouth
. In particular, urinary retention or difficulty in passing urine is a common thiordazine side effect for patients with enlarged prostrates.
Thioridazine has the following structural formula:
• Molecular formula of thioridazine is C21H26N2S2
• Chemical IUPAC Name is 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine
• Molecular weight is 370.5750 g/mol
• Thioridazine available : 10mg tablets, 25mg tablets, 50mg tablets and 100mg tablets.